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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-2026 Volume 34 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Review Open Access

Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

  • Authors:
    • Fatima Zohra Attouahri
    • Imane Chaoui
    • Abdelilah Laraqui
    • Mohamed Rida Tagajdid
    • Mohammed Oukabli
    • Mohammed El Marjany
    • Meriem Khyatti
    • Mohammed Attaleb
    • Mouna Ababou
    • Khalid Ennibi
    • Khaoula Errafii
    • Mohammed El Mzibri

  • View Affiliations / Copyright

    Affiliations: Department of Life Sciences, National Center for Nuclear Energy, Sciences and Techniques (CNESTEN), Rabat 10001, Morocco, Center of Virology, Infectious and Tropical Diseases, Mohammed V Military Teaching Hospital, Rabat 10100, Morocco, Department of Pathology, Mohammed V Military Teaching Hospital, Rabat 10100, Morocco, Department of Radiation Oncology, Mohamed V Military Teaching Hospital, Rabat 10100, Morocco, Laboratory of Genetics, Department of Research, Pasteur Institute of Morocco, Casablanca 20250, Morocco, Laboratory of Biodiversity, Ecology and Genome, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10050, Morocco, African Genome Centre, Mohammed VI Polytechnic University, Benguerir 43150, Morocco
    Copyright: © Attouahri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 204
    |
    Published online on: May 21, 2026
       https://doi.org/10.3892/mmr.2026.13914
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Abstract

Radiotherapy (RT) remains a cornerstone of lung cancer (LC) management, serving as either a definitive treatment or an adjuvant modality following surgical resection. Nevertheless, a major challenge for radiation oncologists is the emergence of radioresistance, whether intrinsic or acquired, which contributes to therapeutic failure, tumor recurrence, metastasis and ultimately to increased patient mortality. Radioresistance is a multifactorial process driven by genetic and epigenetic alterations that dysregulate key signal transduction pathways, enabling cancer cells to survive and adapt under radiotherapeutic stress. A deeper understanding of the molecular mechanisms underlying radioresistance is therefore essential to identify robust biomarkers for patient stratification, prognostication and therapeutic targeting. Such insights could enable individualized treatment strategies within the framework of precision oncology and inform the development of novel radiosensitization approaches to overcome resistance in LC. The present review synthesized current evidence on molecular biomarkers associated with RT resistance in LC.

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Copy and paste a formatted citation
Spandidos Publications style
Attouahri F, Chaoui I, Laraqui A, Tagajdid M, Oukabli M, El Marjany M, Khyatti M, Attaleb M, Ababou M, Ennibi K, Ennibi K, et al: Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review). Mol Med Rep 34: 204, 2026.
APA
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M. ... El Mzibri, M. (2026). Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review). Molecular Medicine Reports, 34, 204. https://doi.org/10.3892/mmr.2026.13914
MLA
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M., Khyatti, M., Attaleb, M., Ababou, M., Ennibi, K., Errafii, K., El Mzibri, M."Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)". Molecular Medicine Reports 34.1 (2026): 204.
Chicago
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M., Khyatti, M., Attaleb, M., Ababou, M., Ennibi, K., Errafii, K., El Mzibri, M."Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)". Molecular Medicine Reports 34, no. 1 (2026): 204. https://doi.org/10.3892/mmr.2026.13914
Copy and paste a formatted citation
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Spandidos Publications style
Attouahri F, Chaoui I, Laraqui A, Tagajdid M, Oukabli M, El Marjany M, Khyatti M, Attaleb M, Ababou M, Ennibi K, Ennibi K, et al: Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review). Mol Med Rep 34: 204, 2026.
APA
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M. ... El Mzibri, M. (2026). Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review). Molecular Medicine Reports, 34, 204. https://doi.org/10.3892/mmr.2026.13914
MLA
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M., Khyatti, M., Attaleb, M., Ababou, M., Ennibi, K., Errafii, K., El Mzibri, M."Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)". Molecular Medicine Reports 34.1 (2026): 204.
Chicago
Attouahri, F., Chaoui, I., Laraqui, A., Tagajdid, M., Oukabli, M., El Marjany, M., Khyatti, M., Attaleb, M., Ababou, M., Ennibi, K., Errafii, K., El Mzibri, M."Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)". Molecular Medicine Reports 34, no. 1 (2026): 204. https://doi.org/10.3892/mmr.2026.13914
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