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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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August-2026 Volume 34 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

  • Authors:
    • Yinhuan Wang
    • Jiefang Guan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, Gansu 730900, P.R. China, Department of Thoracic Surgery, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, Gansu 730900, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 214
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    Published online on: May 29, 2026
       https://doi.org/10.3892/mmr.2026.13924
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Abstract

Metastasis between primary lung cancers and urological malignancies, for example prostate, renal and bladder cancers, poses diagnostic and therapeutic challenges. Previous epidemiological data underscore a frequent bidirectional overlap that adversely affects patient survival. This review synthesizes current molecular insights and clinical implications of this metastatic crosstalk, delineating how these distinct tumor types exploit shared molecular toolkits, including the C‑X‑C chemokine receptor 4/C‑X‑C motif chemokine ligand 12 axis, hepatocyte growth factor/mesenchymal‑epithelial transition factor signaling and epithelial‑mesenchymal plasticity, to facilitate dissemination and colonization. The distinct immune contextures and cellular architectures of the metastatic niche in different organs have also been explored, revealing their notable influence on therapeutic responses. Although molecular profiling and liquid biopsies have been refining diagnostic precision and allowing for a shift toward mechanism‑centric agnostic therapies, organ‑specific microenvironments continue to modulate drug efficacy. Integration of these insights is necessary for advancing personalized management strategies and improving outcomes for patients in this complex clinical setting.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y and Guan J: Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review). Mol Med Rep 34: 214, 2026.
APA
Wang, Y., & Guan, J. (2026). Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review). Molecular Medicine Reports, 34, 214. https://doi.org/10.3892/mmr.2026.13924
MLA
Wang, Y., Guan, J."Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)". Molecular Medicine Reports 34.2 (2026): 214.
Chicago
Wang, Y., Guan, J."Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)". Molecular Medicine Reports 34, no. 2 (2026): 214. https://doi.org/10.3892/mmr.2026.13924
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y and Guan J: Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review). Mol Med Rep 34: 214, 2026.
APA
Wang, Y., & Guan, J. (2026). Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review). Molecular Medicine Reports, 34, 214. https://doi.org/10.3892/mmr.2026.13924
MLA
Wang, Y., Guan, J."Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)". Molecular Medicine Reports 34.2 (2026): 214.
Chicago
Wang, Y., Guan, J."Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)". Molecular Medicine Reports 34, no. 2 (2026): 214. https://doi.org/10.3892/mmr.2026.13924
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