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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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August-2026 Volume 34 Issue 2

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

  • Authors:
    • Huaiyong Li
    • Lili Liu
    • Qingzhu Yang
    • Yao Li
    • Yongli Song
    • Jing Jiang
    • Zhenzhong Wu
    • Weiwei Zhang
    • Baisong Lou

  • View Affiliations / Copyright

    Affiliations: Department of Chemoradiotherapy, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China, Department of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 222
    |
    Published online on: June 8, 2026
       https://doi.org/10.3892/mmr.2026.13932
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Abstract

In the present study, the inhibitory effects of zedoary turmeric oil (ZTO) on non‑small cell lung cancer (NSCLC) were investigated using integrated network pharmacology, molecular docking and in vitro experiments. Treatment with 100 µg/ml ZTO in A549 cells and 50 µM ZTO in H1299 cells markedly reduced cell viability (assessed through an MTT assay), suppressed proliferation (assessed through colony formation/EdU assays) and increased apoptosis (assessed through flow cytometry). Network analysis identified 27 bioactive components (such as curcumadione and zedoradiol) and 96 shared targets with NSCLC. Core targets (including ESR1, EGFR, PIK3CA and PIK3CB) were found to be enriched in the EGFR/PI3K/Akt signaling pathway. Molecular docking demonstrated stable binding between the ZTO components and these targets. Furthermore, reverse transcription‑quantitative PCR and western blotting revealed that ZTO downregulated ESR1 and EGFR expression (P<0.05). These findings suggested that ZTO suppressed NSCLC progression by modulating the EGFR/PI3K/Akt pathway, with its active components potentially targeting key oncogenic regulators. The present study therefore highlights the therapeutic potential of ZTO as a multi‑target agent against NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Liu L, Yang Q, Li Y, Song Y, Jiang J, Wu Z, Zhang W and Lou B: Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer. Mol Med Rep 34: 222, 2026.
APA
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J. ... Lou, B. (2026). Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer. Molecular Medicine Reports, 34, 222. https://doi.org/10.3892/mmr.2026.13932
MLA
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J., Wu, Z., Zhang, W., Lou, B."Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer". Molecular Medicine Reports 34.2 (2026): 222.
Chicago
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J., Wu, Z., Zhang, W., Lou, B."Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer". Molecular Medicine Reports 34, no. 2 (2026): 222. https://doi.org/10.3892/mmr.2026.13932
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Liu L, Yang Q, Li Y, Song Y, Jiang J, Wu Z, Zhang W and Lou B: Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer. Mol Med Rep 34: 222, 2026.
APA
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J. ... Lou, B. (2026). Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer. Molecular Medicine Reports, 34, 222. https://doi.org/10.3892/mmr.2026.13932
MLA
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J., Wu, Z., Zhang, W., Lou, B."Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer". Molecular Medicine Reports 34.2 (2026): 222.
Chicago
Li, H., Liu, L., Yang, Q., Li, Y., Song, Y., Jiang, J., Wu, Z., Zhang, W., Lou, B."Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer". Molecular Medicine Reports 34, no. 2 (2026): 222. https://doi.org/10.3892/mmr.2026.13932
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