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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-2026 Volume 34 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Expression of Concern Open Access

[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

  • Authors:
    • Li Ren
    • Zhouping Li
    • Chunmei Dai
    • Danyu Zhao
    • Yanjie Wang
    • Chunyu Ma
    • Chun Liu

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, P.R. China, Department of Aesthetic and Plastic Surgery, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121004, P.R. China, 3College of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China, College of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 256
    |
    Published online on: July 15, 2026
       https://doi.org/10.3892/mmr.2026.13966
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Abstract

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, concerning the western blot data shown in Figs. 4 and 5 on p. 4380, it was unexpected that the authors would have detected cleaved caspase‑3 in the experiments performed using the MCF‑7 cell line, since it has been shown that MCF‑7 cells do not express caspase‑3 (for example, see the paper by Reiner U. Jänicke and colleagues entitled “MCF‑7 breast carcinoma cells do not express caspase‑3.” Breast Cancer Research and Treatment, vol. 117.1 (2009); p. 219‑221). The authors have been contacted by the Editorial Office to offer an explanation for these unexpected findings in their study, and we are awaiting their response. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further. [Molecular Medicine Reports 17: 4376‑4382, 2018; DOI: 10.3892/mmr.2018.8443]

Mol Med Rep 17: [Related article:] 4376–4382, 2018; DOI: 10.3892/mmr.2018.8443

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, concerning the western blot data shown in Figs. 4 and 5 on p. 4380, it was unexpected that the authors would have detected cleaved caspase-3 in the experiments performed using the MCF-7 cell line, since it has been shown that MCF-7 cells do not express caspase-3 (for example, see the paper by Reiner U. Jänicke and colleagues entitled “MCF-7 breast carcinoma cells do not express caspase-3.” Breast Cancer Research and Treatment, vol. 117.1 (2009); p. 219–221).

The authors have been contacted by the Editorial Office to offer an explanation for these unexpected findings in their study, and we are awaiting their response. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further.

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Copy and paste a formatted citation
Spandidos Publications style
Ren L, Li Z, Dai C, Zhao D, Wang Y, Ma C and Liu C: [Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines. Mol Med Rep 34: 256, 2026.
APA
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., & Liu, C. (2026). [Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines. Molecular Medicine Reports, 34, 256. https://doi.org/10.3892/mmr.2026.13966
MLA
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., Liu, C."[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines". Molecular Medicine Reports 34.3 (2026): 256.
Chicago
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., Liu, C."[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines". Molecular Medicine Reports 34, no. 3 (2026): 256. https://doi.org/10.3892/mmr.2026.13966
Copy and paste a formatted citation
x
Spandidos Publications style
Ren L, Li Z, Dai C, Zhao D, Wang Y, Ma C and Liu C: [Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines. Mol Med Rep 34: 256, 2026.
APA
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., & Liu, C. (2026). [Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines. Molecular Medicine Reports, 34, 256. https://doi.org/10.3892/mmr.2026.13966
MLA
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., Liu, C."[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines". Molecular Medicine Reports 34.3 (2026): 256.
Chicago
Ren, L., Li, Z., Dai, C., Zhao, D., Wang, Y., Ma, C., Liu, C."[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines". Molecular Medicine Reports 34, no. 3 (2026): 256. https://doi.org/10.3892/mmr.2026.13966
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