Angiopoietin-3 overexpression in tobacco smoke-induced mouse lung tumors and its relation to vitamin E intervention

Zhang,Suolian; Chen,Zhaoli; Yang,Jie; Zhao,Guofan; Jin,Min; Shen,Zhiqiang; Wang,Jingfeng; Qiu,Zhigang; Wang,Xinwei; Li,Jun-Wen

doi:10.3892/mmr_00000020

September-October 2008 Volume 1 Issue 5

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September-October 2008 Volume 1 Issue 5

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Article

Angiopoietin-3 overexpression in tobacco smoke-induced mouse lung tumors and its relation to vitamin E intervention

Authors:
- Suolian Zhang
- Zhaoli Chen
- Jie Yang
- Guofan Zhao
- Min Jin
- Zhiqiang Shen
- Jingfeng Wang
- Zhigang Qiu
- Xinwei Wang
- Jun-Wen Li
View Affiliations / Copyright

Affiliations: Tianjin Medical University, Tianjin 300070, P.R. China
Pages: 729-733
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Published online on: September 1, 2008

https://doi.org/10.3892/mmr_00000020
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Abstract

Animal studies have shown that tobacco smoke can induce lung cancer in mice,and that the intake of Vitamin E (VE) has a protective effect against its risk. However, the mechanisms of action of VE remain unclear. In this study, DNA microarrays for gene expression profiles of the mouse genome were applied in order to screen for the upregulated genes associated with VE intervention in smoke-induced lung cancer. Real-time PCR was used to validate the screened upregulated angiopoietin-3 gene (Ang-3), and Western blotting was used to investigate the expression of the Ang-3 protein. Our results demonstrate that smoking and VE intervention involve 621 upregulated genes, including oncogenes, non-oncogenes with clear function and genes with unclear function. Of these, Ang-3 presented high expression in both the smoking and tumor groups. Real-time PCR and Western blotting further indicated that smoking could upregulate the expression of Ang-3; moreover, Ang-3 was overexpressed in lung cancer tissue. VE intervention decreased its expression to some extent. This illustrates that Ang-3 may play an important role in the carcinogenesis and development of smoke-induced lung cancer, and could also be a target in lung cancer treatment.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Angiopoietin-3 overexpression in tobacco smoke-induced mouse lung tumors and its relation to vitamin E intervention

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