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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2009 Volume 2 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2009 Volume 2 Issue 1

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Article

Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia

  • Authors:
    • Chunfang Ha
    • Anneli Stavreus-Evers
    • Britt-Marie Landgren
    • Miriam Mints
    • Margaret C.P. Rees

  • View Affiliations / Copyright

    Affiliations: Ninxia Medical College, Department of Obstetrics and Gynecology, Ningxia, P.R. China
  • Pages: 7-11
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/mmr_00000053
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Abstract

The human endometrium undergoes a unique process of benign angiogenesis under the control of ovarian steroids during reproductive life. Aberrant angiogenesis has been implicated in idiopathic menorrhagia, a common gynaecological complaint. One of the key factors involved in endometrial angiogenesis is adrenomedullin (AM), a multifunctional 52-amino acid peptide. AM mediates the activities of endometrial angiogenesis via calcitonin receptor-like receptor (CLR). The objective of the present study was to compare the endometrial expression of AM and CRL in women with and without idiopathic menorrhagia. Endometrial biopsies were obtained from 9 women with menorrhagia (≥80 ml per menstruation) and 12 women with normal blood loss (<80 ml per menstruation). Protein and mRNA expression levels of AM and CLR were determined using immunohistochemistry and real-time PCR. Compared to the controls, patients with menorrhagia exhibited low immunostaining intensity of AM, while high CLR staining was observed in the epithelium (p<0.05). No difference in mRNA expression was observed between the groups. These data suggest that an imbalance in the AM/CLR system might alter endometrial angiogenesis in menorrhagia.

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Copy and paste a formatted citation
Spandidos Publications style
Ha C, Stavreus-Evers A, Landgren B, Mints M and Rees MC: Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia. Mol Med Rep 2: 7-11, 2009.
APA
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., & Rees, M.C. (2009). Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia. Molecular Medicine Reports, 2, 7-11. https://doi.org/10.3892/mmr_00000053
MLA
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., Rees, M. C."Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia". Molecular Medicine Reports 2.1 (2009): 7-11.
Chicago
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., Rees, M. C."Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia". Molecular Medicine Reports 2, no. 1 (2009): 7-11. https://doi.org/10.3892/mmr_00000053
Copy and paste a formatted citation
x
Spandidos Publications style
Ha C, Stavreus-Evers A, Landgren B, Mints M and Rees MC: Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia. Mol Med Rep 2: 7-11, 2009.
APA
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., & Rees, M.C. (2009). Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia. Molecular Medicine Reports, 2, 7-11. https://doi.org/10.3892/mmr_00000053
MLA
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., Rees, M. C."Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia". Molecular Medicine Reports 2.1 (2009): 7-11.
Chicago
Ha, C., Stavreus-Evers, A., Landgren, B., Mints, M., Rees, M. C."Adrenomedullin and its receptor, calcitonin receptor-like receptor, are aberrantly expressed in women with idiopathic menorrhagia". Molecular Medicine Reports 2, no. 1 (2009): 7-11. https://doi.org/10.3892/mmr_00000053
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