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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2009 Volume 2 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells

  • Authors:
    • Michelle Hanthequeste Bittencourt Dos Santos
    • Andréia Ferreira Eduardo Da Costa
    • Gabriela Da Silva Santos
    • André Luis Souza Dos Santos
    • Prescilla Emy Nagao

  • View Affiliations / Copyright

    Affiliations: Departamento de Biologia Celular, Instituto Biologia Roberto Alcântara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro (UERJ), 20550-013 Rio de Janeiro, RJ, Brazil
  • Pages: 81-84
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/mmr_00000065
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Abstract

In the present study, the influence of the chelating agents of ethylenediaminetetraacetic acid (EDTA), ethylene glycol-bis (β-aminoethyl ether) (EGTA) and 1,10-phenanthroline (PHEN) on growth rate, cytoadherence ability and surface protein expression was examined in a clinical strain of Streptococcus agalactiae isolated from a blood sample. EDTA and EGTA at 10 mM did not inhibit the growth of S. agalactiae, while PHEN significantly arrested bacterial proliferation in a concentration range of 10-0.01 mM. The in vitro interaction between S. agalactiae and A549 cells was a time-dependent process; adherence and bacterial intracellular viability were more pronounced after 3 h of contact. The pre-treatment of bacterial cells with EDTA adversely influenced the adhesive properties of S. agalactiae to A549 cells after 2 and 3 h, whereas EGTA only blocked this process after 3 h. Viable intracellular bacteria were just detected after 3 h of interaction, and EDTA and EGTA inhibited intracellular viability in a similar fashion. Conversely, PHEN inhibited neither the adherence nor the intracellular viability of the microorganism. Furthermore, EDTA robustly suppressed surface polypeptide synthesis, suggesting a decline in the possible bacterial ligands responsible for S. agalactiae adhesive properties.

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Copy and paste a formatted citation
Spandidos Publications style
Dos Santos MH, Da Costa AF, Da Silva Santos G, Dos Santos AL and Nagao PE: Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells. Mol Med Rep 2: 81-84, 2009.
APA
Dos Santos, M.H., Da Costa, A.F., Da Silva Santos, G., Dos Santos, A.L., & Nagao, P.E. (2009). Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells. Molecular Medicine Reports, 2, 81-84. https://doi.org/10.3892/mmr_00000065
MLA
Dos Santos, M. H., Da Costa, A. F., Da Silva Santos, G., Dos Santos, A. L., Nagao, P. E."Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells". Molecular Medicine Reports 2.1 (2009): 81-84.
Chicago
Dos Santos, M. H., Da Costa, A. F., Da Silva Santos, G., Dos Santos, A. L., Nagao, P. E."Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells". Molecular Medicine Reports 2, no. 1 (2009): 81-84. https://doi.org/10.3892/mmr_00000065
Copy and paste a formatted citation
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Spandidos Publications style
Dos Santos MH, Da Costa AF, Da Silva Santos G, Dos Santos AL and Nagao PE: Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells. Mol Med Rep 2: 81-84, 2009.
APA
Dos Santos, M.H., Da Costa, A.F., Da Silva Santos, G., Dos Santos, A.L., & Nagao, P.E. (2009). Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells. Molecular Medicine Reports, 2, 81-84. https://doi.org/10.3892/mmr_00000065
MLA
Dos Santos, M. H., Da Costa, A. F., Da Silva Santos, G., Dos Santos, A. L., Nagao, P. E."Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells". Molecular Medicine Reports 2.1 (2009): 81-84.
Chicago
Dos Santos, M. H., Da Costa, A. F., Da Silva Santos, G., Dos Santos, A. L., Nagao, P. E."Effect of chelating agents on the growth, surface polypeptide synthesis and interaction of Streptococcus agalactiae with human epithelial cells". Molecular Medicine Reports 2, no. 1 (2009): 81-84. https://doi.org/10.3892/mmr_00000065
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