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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2009 Volume 2 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin

  • Authors:
    • Pablo Lorenzano Menna
    • Romina L. Parera
    • Georgina A. Cardama
    • Daniel F. Alonso
    • Daniel E. Gomez
    • Hernan G. Farina

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, Buenos Aires, Argentina
  • Pages: 97-102
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/mmr_00000068
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Abstract

The statins, a family of cholesterol-lowering drugs, are known to block the formation of isoprenoids. They thus affect the small GTPase Rho, which requires attachment to cell membranes for proper signaling activity. Chimaerins are GTPase-activating proteins (GAPs) that accelerate GTP hydrolysis from Rac, another GTPase of the same family. We explored the cooperative antitumor effects of the overexpression of β2-chimaerin in combination with statins. F3II mouse mammary carcinoma cells transfected with the β2-chimaerin GAP domain exhibiting low intracellular levels of active Rac-GTP were exposed in vitro to a panel of statins. Transfectants were significantly more sensitive to the cytostatic effects of lovastatin, simvastatin, atorvastatin and rosuvastatin than untransfected F3II cells with high Rac-GTP levels. Transfected tumor cells also showed a higher sensitivity for detachment from the substrate and for apoptosis after statin exposure. We further checked the cytostatic effect of statins in combination with azathioprine, a compound that specifically blocks Rac1 activation. Combined treatment with simvastatin and azathioprine demonstrated an enhanced growth-inhibitory effect on control F3II cells. Our data suggest that the combination of statins with a reduction in active Rac levels can produce a cooperative antitumor effect on breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Menna PL, Parera RL, Cardama GA, Alonso DF, Gomez DE and Farina HG: Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin. Mol Med Rep 2: 97-102, 2009.
APA
Menna, P.L., Parera, R.L., Cardama, G.A., Alonso, D.F., Gomez, D.E., & Farina, H.G. (2009). Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin. Molecular Medicine Reports, 2, 97-102. https://doi.org/10.3892/mmr_00000068
MLA
Menna, P. L., Parera, R. L., Cardama, G. A., Alonso, D. F., Gomez, D. E., Farina, H. G."Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin". Molecular Medicine Reports 2.1 (2009): 97-102.
Chicago
Menna, P. L., Parera, R. L., Cardama, G. A., Alonso, D. F., Gomez, D. E., Farina, H. G."Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin". Molecular Medicine Reports 2, no. 1 (2009): 97-102. https://doi.org/10.3892/mmr_00000068
Copy and paste a formatted citation
x
Spandidos Publications style
Menna PL, Parera RL, Cardama GA, Alonso DF, Gomez DE and Farina HG: Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin. Mol Med Rep 2: 97-102, 2009.
APA
Menna, P.L., Parera, R.L., Cardama, G.A., Alonso, D.F., Gomez, D.E., & Farina, H.G. (2009). Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin. Molecular Medicine Reports, 2, 97-102. https://doi.org/10.3892/mmr_00000068
MLA
Menna, P. L., Parera, R. L., Cardama, G. A., Alonso, D. F., Gomez, D. E., Farina, H. G."Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin". Molecular Medicine Reports 2.1 (2009): 97-102.
Chicago
Menna, P. L., Parera, R. L., Cardama, G. A., Alonso, D. F., Gomez, D. E., Farina, H. G."Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin". Molecular Medicine Reports 2, no. 1 (2009): 97-102. https://doi.org/10.3892/mmr_00000068
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