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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2009 Volume 2 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2009 Volume 2 Issue 1

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Article

Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells

  • Authors:
    • Yin-Lin Ge
    • Jin-Yu Zhang
    • Xiao Zhang
    • Lin Hou
    • Quan Li
    • Mei-Lan Xue

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Medical College, Qingdao University, Shandong 266021, P.R. China. geyinlin@126.com
  • Pages: 121-127
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/mmr_00000072
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Abstract

Vascular endothelial growth factor receptor-2 or kinase insert domain-containing receptor (VEGFR2/KDR) is secreted by most solid tumors, including breast cancer, and is an important mediator of angiogenesis. To observe the effects of KDR gene expression on cell proliferation and the cell cycle in MCF-7 cells in vitro and in vivo, we used chemically modified siRNA directed against KDR. The results revealed that chemically modified siRNA transfection of the KDR gene effectively inhibited the proliferation of MCF-7 cells, arrested cells in the G1 phase and down-regulated the expression of KDR. In addition, in the progression of cell cycle arrest induced by siRNA, phosphorylated ERK and CDK1 expression was down-regulated (P<0.01). In vivo, the growth of tumors was visibly suppressed. RT-PCR and the results of immunohistochemistry indicated that KDR mRNA and protein expression was reduced in the excised tumors. In contrast, there were no obvious changes in the control groups. This implies that chemically modified KDR siRNA markedly decreases KDR gene expression and inhibits cellular proliferation in vitro, as well as suppressing tumor growth in a xenograft model. KDR may be a new target for breast cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Ge Y, Zhang J, Zhang X, Hou L, Li Q and Xue M: Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells. Mol Med Rep 2: 121-127, 2009.
APA
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., & Xue, M. (2009). Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells. Molecular Medicine Reports, 2, 121-127. https://doi.org/10.3892/mmr_00000072
MLA
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., Xue, M."Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells". Molecular Medicine Reports 2.1 (2009): 121-127.
Chicago
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., Xue, M."Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells". Molecular Medicine Reports 2, no. 1 (2009): 121-127. https://doi.org/10.3892/mmr_00000072
Copy and paste a formatted citation
x
Spandidos Publications style
Ge Y, Zhang J, Zhang X, Hou L, Li Q and Xue M: Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells. Mol Med Rep 2: 121-127, 2009.
APA
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., & Xue, M. (2009). Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells. Molecular Medicine Reports, 2, 121-127. https://doi.org/10.3892/mmr_00000072
MLA
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., Xue, M."Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells". Molecular Medicine Reports 2.1 (2009): 121-127.
Chicago
Ge, Y., Zhang, J., Zhang, X., Hou, L., Li, Q., Xue, M."Chemically modified siRNA directed against the KDR gene inhibits the proliferation of breast cancer cells". Molecular Medicine Reports 2, no. 1 (2009): 121-127. https://doi.org/10.3892/mmr_00000072
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