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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma

  • Authors:
    • Qiang Liu
    • Ling-Jun Song
    • Wei-Qing Xu
    • Lei Zhao
    • Lin Zheng
    • Zhao-Wen Yan
    • Guo-Hui Fu

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R.China
  • Pages: 169-174
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000079
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Abstract

The tumor suppressor p16 is a negative regulator of the cell cycle, commonly believed to act in the nucleus. We recently found that p16 protein is expressed in the cytoplasm of gastric cancer cells, concomitantly with anion exchanger 1 (AE1). The aim of this study was to analyze the significance of cytoplasmic p16 and its relationship to AE1 in the progression of gastric cancer. Expression of p16 and AE1 was examined by immunohistochemical analysis in 196 patients; 98 with early gastric cancer and 98 with advanced gastric cancer. The relationship between cytoplasmic p16 and clinicopathological features, and the relationship between cytoplasmic p16 and AE1, were analyzed statistically. Expression of p16 was observed in the nucleus in early stage gastric cancer, but was located mainly in the cytoplasm in advanced cancer cells. Furthermore, cytoplasmic expression of p16 was correlated with AE1 expression, and both were associated with the absence of lymph metastasis in gastric cancer. In conclusion, cytoplasmic immunoreactivity of p16 appears to be a good prognostic indicator in advanced gastric cancer. Co-localization of p16 and AE1 predicts a lack of metastasis in gastric cancer. The role of cytoplasmic p16 and AE1, and the mechanisms involved in the progression of gastric cancer, warrant further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Song L, Xu W, Zhao L, Zheng L, Yan Z and Fu G: Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Mol Med Rep 2: 169-174, 2009.
APA
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., & Fu, G. (2009). Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Molecular Medicine Reports, 2, 169-174. https://doi.org/10.3892/mmr_00000079
MLA
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., Fu, G."Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma". Molecular Medicine Reports 2.2 (2009): 169-174.
Chicago
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., Fu, G."Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma". Molecular Medicine Reports 2, no. 2 (2009): 169-174. https://doi.org/10.3892/mmr_00000079
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Song L, Xu W, Zhao L, Zheng L, Yan Z and Fu G: Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Mol Med Rep 2: 169-174, 2009.
APA
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., & Fu, G. (2009). Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Molecular Medicine Reports, 2, 169-174. https://doi.org/10.3892/mmr_00000079
MLA
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., Fu, G."Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma". Molecular Medicine Reports 2.2 (2009): 169-174.
Chicago
Liu, Q., Song, L., Xu, W., Zhao, L., Zheng, L., Yan, Z., Fu, G."Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma". Molecular Medicine Reports 2, no. 2 (2009): 169-174. https://doi.org/10.3892/mmr_00000079
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