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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-April 2009 Volume 2 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Copy number variation and susceptibility to human disorders (Review)

Barkur S. Shastry
Pages: 143-147
Published online on: 01 March 2009

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Article

Site-specific induction of intestinal hypoxia-inducible factor-1α after hemorrhagic shock

Hiroyuki Nishie, Toru Takahashi, Kazuyoshi Inoue, Hiroko Shimizu, Hiroshi Morimatsu, Yuichiro Toda, Emiko Omori, Reiko Akagi, Hiroshi Katayama, Kiyoshi Morita
Pages: 149-152
Published online on: 01 March 2009

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Article

MEK1 gene mutation in Japanese lung adenocarcinoma patients

Hidefumi Sasaki, Yu Hikosaka, Katsuhiro Okuda, Osamu Kawano, Haruhiro Yukiue, Motoki Yano, Yoshitaka Fujii
Pages: 153-155
Published online on: 01 March 2009

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Article Open Access

Positive emotion-specific changes in the gene expression profile of tickled rats

Miyo Hori, Takashi Hayashi, Yoshimi Nakagawa, Shigeko Sakamoto, Osamu Urayama, Kazuo Murakami
Pages: 157-161
Published online on: 01 March 2009

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Article

Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis

Masahide Matsuyama, Kiyoaki Funao, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Tatsuya Nakatani, Rikio Yoshimura
Pages: 163-167
Published online on: 01 March 2009

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Article

Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma

Qiang Liu, Ling-Jun Song, Wei-Qing Xu, Lei Zhao, Lin Zheng, Zhao-Wen Yan, Guo-Hui Fu
Pages: 169-174
Published online on: 01 March 2009

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Article

Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential

Raphael Bar-Or, Leonard T. Rael, C. Gerald Curtis, Charles W. Mains, Denetta S. Slone, David Bar-Or
Pages: 175-180
Published online on: 01 March 2009

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Article

Activation of the PI3K-AKT pathway in human malignant mesothelioma cells

Yutaro Suzuki, Hideki Murakami, Koji Kawaguchi, Tetsuo Tanigushi, Makiko Fujii, Keiko Shinjo, Yutaka Kondo, Hirotaka Osada, Kaoru Shimokata, Yoshitsugu Horio, Yoshinori Hasegawa, Toyoaki Hida, Yoshitaka Sekido
Pages: 181-188
Published online on: 01 March 2009

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Article

Direct effects of CPT-11 and SN38 on ovarian granulosa cells

Tomoko Utsunomiya, Tetsuji Tanaka, Hirotoshi Utsunomiya, Naohiko Umesaki
Pages: 189-192
Published online on: 01 March 2009

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Article

Telmisartan as a peroxisome proliferator-activated receptor-γ ligand is a new target in the treatment of human renal cell carcinoma

Kiyoaki Funao, Masahide Matsuyama, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Tatsuya Nakatani, Rikio Yoshimura
Pages: 193-198
Published online on: 01 March 2009

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Article

Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinasein the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one

Akira Takasaki, Haruo Hanyu, Toshihiko Iwamoto, Ken Shirato, Ryutaro Izumi, Hiroko Toyota, Junichiro Mizuguchi, Keisuke Miyazawa, Akio Tomoda
Pages: 199-203
Published online on: 01 March 2009

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Article

Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease

Mitsutoshi Oguri, Kimihiko Kato, Kiyoshi Yokoi, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yukitoshi Aoyagi, Yutaka Nishigaki, Hideyo Yoshida, Yoshinori Nozawa, Yoshiji Yamada
Pages: 205-211
Published online on: 01 March 2009

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Article

Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats

Yen-Chang Lai, Takashi Yuri, Norihisa Uehara, Yoichiro Matsuoka, Sayaka Kanematsu, Airo Tsubura
Pages: 213-220
Published online on: 01 March 2009

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Article

Euphorbiae humifusae induces apoptosis in Hep3B hepatocarcinoma cells via simultaneous activation of the death receptor-mediated and mitochondrial pathways

Sang Ho Seo, Dong Yeok Shin, Su Hyun Hong, Sang Eun Park, Yung Hyun Choi, Sang Hoon Hong
Pages: 221-227
Published online on: 01 March 2009

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Article

Mechanical stress up-regulates RANKL expression via the VEGF autocrine pathway in osteoblastic MC3T3-E1 cells

Takeshi Nakai, Yoshitaka Yoshimura, Yoshiaki Deyama, Kuniaki Suzuki, Junichiro Iida
Pages: 229-234
Published online on: 01 March 2009

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Article

MicroRNA-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma

Yoichiro Mori, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Ryo Ogawa, Takeyasu Katada, Koshiro Harata, Tatsuya Tanaka, Midori Shiozaki, Yoshitaka Fujii
Pages: 235-239
Published online on: 01 March 2009

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Article

Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells

Vincenzo Martino, Annalisa Bianchera, Laura Reia, Ovidio Bussolati, Raffaella Fazzina, Flora Marino, Luca Montemurro, Roberto Tonelli, Andrea Pession, Gian Carlo Gazzola, Roberto Sala
Pages: 241-244
Published online on: 01 March 2009

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Article

Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline

Ji Li, Wei Liu, Kongbo Zhao, Yongkui Zhang, Xin Li, Qiang Yang, Zhenfeng Li, Jianmin Li
Pages: 245-252
Published online on: 01 March 2009

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Article

Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome

Iván G. Palomo, César L. Gutiérrez, Marcelo L. Alarcón, Julio C. Jaramillo, Fabián M. Segovia, Elba M. Leiva, Verónica E. Mujica, Gloria N. Icaza, Nora S. Díaz, Rodrigo Moore-Carrasco
Pages: 253-257
Published online on: 01 March 2009

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Article

Genotype <21CAs/≥21CAs and allele <21CAs of the MANBA gene in melanoma risk and progression in a Swedish population

H. Bu, I. Rosdahl, X.-F. Sun, H. Zhang
Pages: 259-263
Published online on: 01 March 2009

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Article

Is the RET proto-oncogene involved in the pathogenesis of intestinal neuronal dysplasia type B?

Raquel María Fernández, Avencia Sánchez-Mejías, Maria Macarena Ruiz-Ferrer, Manuel López-Alonso, Guillermo Antiñolo, Salud Borrego
Pages: 265-270
Published online on: 01 March 2009

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Article

Betulinic acid does not modulate the activity of P-gp/ABCB1 or MRP1/ABCC1 in a non-tumoral renal cell line: Possible utility in multidrug resistance cancer chemotherapy

João Marcos Delou, Márcia Alves Marques Capella, Cerli Rocha Gattass
Pages: 271-275
Published online on: 01 March 2009

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Article

Common variants of the TLR9 gene influence the clinical course of HBV infection

Nina Jia, Qing Xie, Lanyi Lin, Honglian Gui, Hui Wang, Shan Jiang, Hong Yu, Qing Guo
Pages: 277-281
Published online on: 01 March 2009

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Article

Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer

Zhonggan Jin, Qing Lu, Danhong Ge, Ming Zong, Qinghui Zhu
Pages: 283-289
Published online on: 01 March 2009

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Article

MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis

Yu-Sheng Lin, Shih-Ming Jung, Chun-Nan Yeh, Yung-Chang Chen, Feng-Chun Tsai, Tzu-Fang Shiu, Hsueh-Hua Wu, Pyng-Jing Lin, Pao-Hsien Chu
Pages: 291-294
Published online on: 01 March 2009

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Article

Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis

Yihong Shen, Qing Wang, Qiong Zhao, Jianying Zhou
Pages: 295-299
Published online on: 01 March 2009

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Article

Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro

Donghui Mi, Yanguang Gao, Sheng Zheng, Xueqing Ba, Xianlu Zeng
Pages: 301-306
Published online on: 01 March 2009

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Article

Anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), SOD or catalase on antimycin A-induced HeLa cell death

Yong Hwan Han, Suhn Hee Kim, Sung Zoo Kim, Woo Hyun Park
Pages: 307-311
Published online on: 01 March 2009

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Article

Pim-1 activation of cell motility induces the malignant phenotype of tongue carcinoma

Souichi Tanaka, Tetsuya Kitamura, Fumihiro Higashino, Kyoko Hida, Yoichi Ohiro, Mitsunobu Ono, Masanobu Kobayashi, Yasunori Totsuka, Masanobu Shindoh
Pages: 313-318
Published online on: 01 March 2009

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Article

Radiotherapy-induced decreases in substance P levels may potentiate melanoma growth

Aylin Fidan Korcum, Salih Sanlioglu, Gamze Aksu, Nina Tuncel, Nuray Erin
Pages: 319-326
Published online on: 01 March 2009

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Article

Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine

Wei Zhao, Xin-Sheng Wang, Hai-Tao Niu, Li-Li Wang, Bang-Min Han, Shu-Jie Xia
Pages: 327-331
Published online on: 01 March 2009

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Journal Cover
January-2026 Volume 33 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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Article Open Access

FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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Article Open Access

NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Article Open Access

Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Review Open Access

Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Article Open Access

Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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Article Open Access

TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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Article Open Access

CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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Article Open Access

High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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Correction Open Access

[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Article Open Access

Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Article Open Access

Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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Article Open Access

CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Article Open Access

Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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Retraction Open Access

[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Review Open Access

Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Review Open Access

Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Review Open Access

Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Review Open Access

Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Article Open Access

Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Review Open Access

Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Article Open Access

Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Review Open Access

Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Review Open Access

Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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Article Open Access

MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Review Open Access

Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Article Open Access

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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Review Open Access

The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

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Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
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Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

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Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

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Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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