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Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline

  • Authors:
    • Ji Li
    • Wei Liu
    • Kongbo Zhao
    • Yongkui Zhang
    • Xin Li
    • Qiang Yang
    • Zhenfeng Li
    • Jianmin Li

  • View Affiliations

  • Published online on: March 1, 2009     https://doi.org/10.3892/mmr_00000091
  • Pages: 245-252
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

P-glycoprotein (P-gp) overexpression and tumor stem cells are thought to be important factors in the cross-resistance of cancer cells. There have been no studies on whether diallyl trisulfide (DATS) can reverse drug resistance in human osteosarcoma cells. In the present study, we demonstrated that DATS down-regulated P-gp expression and reversed drug resistance. DATS and methotrexate (MTX) decreased the ratio of drug-resistant human osteosarcoma cells positive for CD133 (a tumor stem cell marker). To the best of our knowledge, this is the first evidence that DATS can reverse drug resistance and lower the ratio of CD133+ cells in human osteosarcoma cells in conjunction with MTX.

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March-April 2009
Volume 2 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Li J, Liu W, Zhao K, Zhang Y, Li X, Yang Q, Li Z and Li J: Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline. Mol Med Rep 2: 245-252, 2009
APA
Li, J., Liu, W., Zhao, K., Zhang, Y., Li, X., Yang, Q. ... Li, J. (2009). Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline. Molecular Medicine Reports, 2, 245-252. https://doi.org/10.3892/mmr_00000091
MLA
Li, J., Liu, W., Zhao, K., Zhang, Y., Li, X., Yang, Q., Li, Z., Li, J."Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline". Molecular Medicine Reports 2.2 (2009): 245-252.
Chicago
Li, J., Liu, W., Zhao, K., Zhang, Y., Li, X., Yang, Q., Li, Z., Li, J."Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline". Molecular Medicine Reports 2, no. 2 (2009): 245-252. https://doi.org/10.3892/mmr_00000091