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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Common variants of the TLR9 gene influence the clinical course of HBV infection

  • Authors:
    • Nina Jia
    • Qing Xie
    • Lanyi Lin
    • Honglian Gui
    • Hui Wang
    • Shan Jiang
    • Hong Yu
    • Qing Guo

  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 277-281
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000096
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Abstract

Hepatitis B virus (HBV) infection leads to the development of liver inflammation, causing morbidity and mortality. Multiple factors influence HBV progression, including genetic factors. Toll-like receptor (TLR)9 plays a key role in innate immunity, and mutations in the genes encoding this receptor have been associated with liver damage progression. Our study aimed to investigate one-tag single nucleotide polymorphisms (rs187084) representing the majority of common variations in TLR9 in a population-based study of Chinese patients. A total of 209 Chinese patients with HBV infection (130 with chronic hepatitis and 79 with liver cirrhosis) and 193 healthy individuals were studied. Our results showed that the frequencies of the C/C genotype and C allele were statistically higher in patients with HBV-related liver cirrhosis than in the healthy controls (26.6 vs. 15.5%; OR=1.97, 95% CI 1.05-3.71, χ2=4.483, P=0.034/43.1 vs. 37.8%; OR=1.49, 95% CI 1.02-2.16, χ2=4.323, P=0.038). No significant differences in the frequencies of alleles or genotypes were found between patients with chronic hepatitis B and the control subjects. In conclusion, this study is the first to show that small effects within TLR9 contribute towards the development of HBV, supporting the hypothesis that little is currently known regarding the contribution of genetic factors to HBV.

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Copy and paste a formatted citation
Spandidos Publications style
Jia N, Xie Q, Lin L, Gui H, Wang H, Jiang S, Yu H and Guo Q: Common variants of the TLR9 gene influence the clinical course of HBV infection . Mol Med Rep 2: 277-281, 2009.
APA
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S. ... Guo, Q. (2009). Common variants of the TLR9 gene influence the clinical course of HBV infection . Molecular Medicine Reports, 2, 277-281. https://doi.org/10.3892/mmr_00000096
MLA
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S., Yu, H., Guo, Q."Common variants of the TLR9 gene influence the clinical course of HBV infection ". Molecular Medicine Reports 2.2 (2009): 277-281.
Chicago
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S., Yu, H., Guo, Q."Common variants of the TLR9 gene influence the clinical course of HBV infection ". Molecular Medicine Reports 2, no. 2 (2009): 277-281. https://doi.org/10.3892/mmr_00000096
Copy and paste a formatted citation
x
Spandidos Publications style
Jia N, Xie Q, Lin L, Gui H, Wang H, Jiang S, Yu H and Guo Q: Common variants of the TLR9 gene influence the clinical course of HBV infection . Mol Med Rep 2: 277-281, 2009.
APA
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S. ... Guo, Q. (2009). Common variants of the TLR9 gene influence the clinical course of HBV infection . Molecular Medicine Reports, 2, 277-281. https://doi.org/10.3892/mmr_00000096
MLA
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S., Yu, H., Guo, Q."Common variants of the TLR9 gene influence the clinical course of HBV infection ". Molecular Medicine Reports 2.2 (2009): 277-281.
Chicago
Jia, N., Xie, Q., Lin, L., Gui, H., Wang, H., Jiang, S., Yu, H., Guo, Q."Common variants of the TLR9 gene influence the clinical course of HBV infection ". Molecular Medicine Reports 2, no. 2 (2009): 277-281. https://doi.org/10.3892/mmr_00000096
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