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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus

  • Authors:
    • Lori Holle
    • Wen Song
    • Eric Holle
    • Jennifer Nilsson
    • Yangzhang Wei
    • Jinhua Li
    • Thomas E. Wagner
    • Xianzhong Yu

  • View Affiliations / Copyright

    Affiliations: Oncology Research Institute of the Greenville Hospital System, Greenville, SC 29605, USA
  • Pages: 399-403
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000112
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Abstract

We previously designed a pro-cytolytic peptide to target prostate-specific membrane antigen (PSMA)-positive prostate tumor cells. The backbone of the peptide was derived from the cell lytic amoebapore H-3 domain, which becomes completely inactive upon modification by two glutamate residues linked to the ε-amide group of the COOH-terminal lysine through γ-linkages (H-3Glu2). This modified H-3 domain regains its lytic activity against PSMA-positive cells (LNCaP) after the γ-linked glutamate residues are cleaved by PSMA. Our previous in vitro results demonstrate that the modified amoebapore peptide has strong cytolytic activity towards PSMA-positive cells and very little activity towards PSMA-negative cells. In the present study, the in vivo efficacy of this modified peptide was examined in human LNCaP prostate tumor xenografts in nude mice. The results showed significantly decreased tumor size and PSA levels in treated mice as compared to control mice. As well, 5/12 of the treated mice were tumor-free. Peptide distribution studies showed that peptide levels in the prostate tumors maintained a steady concentration for approximately 6 hours. Single-dose toxicity studies showed no toxic effects of the peptide when administered intraperitoneally or intravenously at a dose of 30 mg/kg.

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Copy and paste a formatted citation
Spandidos Publications style
Holle L, Song W, Holle E, Nilsson J, Wei Y, Li J, Wagner TE and Yu X: In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus. Mol Med Rep 2: 399-403, 2009.
APA
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J. ... Yu, X. (2009). In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus. Molecular Medicine Reports, 2, 399-403. https://doi.org/10.3892/mmr_00000112
MLA
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J., Wagner, T. E., Yu, X."In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus". Molecular Medicine Reports 2.3 (2009): 399-403.
Chicago
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J., Wagner, T. E., Yu, X."In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus". Molecular Medicine Reports 2, no. 3 (2009): 399-403. https://doi.org/10.3892/mmr_00000112
Copy and paste a formatted citation
x
Spandidos Publications style
Holle L, Song W, Holle E, Nilsson J, Wei Y, Li J, Wagner TE and Yu X: In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus. Mol Med Rep 2: 399-403, 2009.
APA
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J. ... Yu, X. (2009). In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus. Molecular Medicine Reports, 2, 399-403. https://doi.org/10.3892/mmr_00000112
MLA
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J., Wagner, T. E., Yu, X."In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus". Molecular Medicine Reports 2.3 (2009): 399-403.
Chicago
Holle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J., Wagner, T. E., Yu, X."In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus". Molecular Medicine Reports 2, no. 3 (2009): 399-403. https://doi.org/10.3892/mmr_00000112
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