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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation

  • Authors:
    • Choon-Taek Lee
    • Mi Young Park
    • Dal Rae Kim
    • Eun Kyung Choi
    • Chul-Gyu Yoo
    • Young Whan Kim
    • Sung Koo Han
    • Young-Soo Shim
    • Yeon-Soo Kim

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea. ctlee@snu.ac.kr
  • Pages: 471-475
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000123
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Abstract

Radiation is one of the main treatment modalities in lung cancer, but low sensitivity and acquired resistance of lung cancer cells to radiation frequently result in treatment failure. The activation of nuclear factor (NF)-κB is reportedly the main mechanism by which cancer cells exhibit resistance to external stresses, such as chemotherapy or radiation therapy. In this study, we blocked the activation of NF-κB by adenovirus-expressing IκBα-SR and investigated the effect this had on radiation sensitivity. Transduction with ad-IκBα effectively blocked the activation of NF-κB by radiation in all the cancer cell lines tested, except for NCI H460. Clonogenic assay after radiation demonstrated that ad-IκBα transduction enhanced the sensitivity to radiation of the lung cancer cell lines and HeLa cells, except for NCI H460. The radiosensitizing effect of IκBα was more potent in lung cancer cell lines with radioresistance (SKMESres) (sensitizer enhancement ratio 1:61). From these findings, NF-κB blockade by ad-IκBα enhanced the radiation sensitivity and also abolished the acquired radiation resistance of lung cancer cell lines. This study provides a therapeutic rationale for combining an NF-κB-blocking strategy with radiation to both increase sensitivity and overcome acquired resistance to radiation.

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Copy and paste a formatted citation
Spandidos Publications style
Lee C, Park MY, Kim DR, Choi EK, Yoo C, Kim YW, Han SK, Shim Y and Kim Y: Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation. Mol Med Rep 2: 471-475, 2009.
APA
Lee, C., Park, M.Y., Kim, D.R., Choi, E.K., Yoo, C., Kim, Y.W. ... Kim, Y. (2009). Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation. Molecular Medicine Reports, 2, 471-475. https://doi.org/10.3892/mmr_00000123
MLA
Lee, C., Park, M. Y., Kim, D. R., Choi, E. K., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Kim, Y."Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation". Molecular Medicine Reports 2.3 (2009): 471-475.
Chicago
Lee, C., Park, M. Y., Kim, D. R., Choi, E. K., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Kim, Y."Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation". Molecular Medicine Reports 2, no. 3 (2009): 471-475. https://doi.org/10.3892/mmr_00000123
Copy and paste a formatted citation
x
Spandidos Publications style
Lee C, Park MY, Kim DR, Choi EK, Yoo C, Kim YW, Han SK, Shim Y and Kim Y: Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation. Mol Med Rep 2: 471-475, 2009.
APA
Lee, C., Park, M.Y., Kim, D.R., Choi, E.K., Yoo, C., Kim, Y.W. ... Kim, Y. (2009). Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation. Molecular Medicine Reports, 2, 471-475. https://doi.org/10.3892/mmr_00000123
MLA
Lee, C., Park, M. Y., Kim, D. R., Choi, E. K., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Kim, Y."Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation". Molecular Medicine Reports 2.3 (2009): 471-475.
Chicago
Lee, C., Park, M. Y., Kim, D. R., Choi, E. K., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Kim, Y."Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation". Molecular Medicine Reports 2, no. 3 (2009): 471-475. https://doi.org/10.3892/mmr_00000123
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