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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-August 2009 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2009 Volume 2 Issue 4

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Article

Arachidonic acid pathway: A molecular target in human testicular cancer (Review)

  • Authors:
    • Masahide Matsuyama
    • Rikio Yoshimura

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
  • Pages: 527-531
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/mmr_00000131
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Abstract

Recent epidemiological studies and animal experiments have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX), the first oxidase in the process of prostaglandin production from arachidonic acid, is the principal target of NSAIDs. Due to its inhibition by NSAIDs, the COX enzyme may be involved in the initiation and/or promotion of carcinogenesis. Lipoxygenase (LOX) is also an enzyme active in the early stages of the pathway for producing leukotrienes from arachidonic acid, and may, like COX, be involved in the initiation and/or promotion of carcinogenesis. Peroxisome proliferator activator-receptor (PPAR)-γ is a ligand-activated transcriptional factor belonging to the steroid receptor super-family. PPAR-γ plays a role in both adipocyte differentiation and carcinogenesis, and is a target for the cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human testicular cancer tissues, as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligands.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuyama M and Yoshimura R: Arachidonic acid pathway: A molecular target in human testicular cancer (Review) . Mol Med Rep 2: 527-531, 2009.
APA
Matsuyama, M., & Yoshimura, R. (2009). Arachidonic acid pathway: A molecular target in human testicular cancer (Review) . Molecular Medicine Reports, 2, 527-531. https://doi.org/10.3892/mmr_00000131
MLA
Matsuyama, M., Yoshimura, R."Arachidonic acid pathway: A molecular target in human testicular cancer (Review) ". Molecular Medicine Reports 2.4 (2009): 527-531.
Chicago
Matsuyama, M., Yoshimura, R."Arachidonic acid pathway: A molecular target in human testicular cancer (Review) ". Molecular Medicine Reports 2, no. 4 (2009): 527-531. https://doi.org/10.3892/mmr_00000131
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuyama M and Yoshimura R: Arachidonic acid pathway: A molecular target in human testicular cancer (Review) . Mol Med Rep 2: 527-531, 2009.
APA
Matsuyama, M., & Yoshimura, R. (2009). Arachidonic acid pathway: A molecular target in human testicular cancer (Review) . Molecular Medicine Reports, 2, 527-531. https://doi.org/10.3892/mmr_00000131
MLA
Matsuyama, M., Yoshimura, R."Arachidonic acid pathway: A molecular target in human testicular cancer (Review) ". Molecular Medicine Reports 2.4 (2009): 527-531.
Chicago
Matsuyama, M., Yoshimura, R."Arachidonic acid pathway: A molecular target in human testicular cancer (Review) ". Molecular Medicine Reports 2, no. 4 (2009): 527-531. https://doi.org/10.3892/mmr_00000131
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