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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-August 2009 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2009 Volume 2 Issue 4

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Article

Analysis of miR-221 and p27 expression in human gliomas

  • Authors:
    • Xiaoming Lu
    • Peng Zhao
    • Chunzhi Zhang
    • Zhen Fu
    • Yunxiang Chen
    • Ailing Lu
    • Nin Liu
    • Yongping You
    • Peiyu Pu
    • Chunsheng Kang

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 651-656
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/mmr_00000152
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Abstract

MicroRNAs (miRNAs) are short (≈22-nt) non-coding RNA molecules implicated in both development and disease that act by repressing translation or by inducing the cleavage of target RNA transcripts. Emerging evidence suggests that the altered regulation of miRNA may be involved in the pathogenesis of cancer. Here, we investigated the expression of the miRNA gene miR-221 by real-time PCR in human glioma tissues of varying grades of malignancy. The expression level of miR-221 was found to increase with glioma malignancy, whereas protein levels of a putative target, the cell cycle inhibitor and tumor suppressor gene p27Kip1, decreased. Using a luciferase reporter assay, we further confirmed the translational repression activity of miR-221 on p27 by identifying the target recognition element within the 3'UTR of p27. Our results suggest that miR-221 is a regulator of the tumor suppressor gene p27, and that its increased expression in advanced gliomas might contribute to glioma cell proliferation by a mechanism involving the repression of p27.

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Copy and paste a formatted citation
Spandidos Publications style
Lu X, Zhao P, Zhang C, Fu Z, Chen Y, Lu A, Liu N, You Y, Pu P, Kang C, Kang C, et al: Analysis of miR-221 and p27 expression in human gliomas . Mol Med Rep 2: 651-656, 2009.
APA
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A. ... Kang, C. (2009). Analysis of miR-221 and p27 expression in human gliomas . Molecular Medicine Reports, 2, 651-656. https://doi.org/10.3892/mmr_00000152
MLA
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A., Liu, N., You, Y., Pu, P., Kang, C."Analysis of miR-221 and p27 expression in human gliomas ". Molecular Medicine Reports 2.4 (2009): 651-656.
Chicago
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A., Liu, N., You, Y., Pu, P., Kang, C."Analysis of miR-221 and p27 expression in human gliomas ". Molecular Medicine Reports 2, no. 4 (2009): 651-656. https://doi.org/10.3892/mmr_00000152
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Zhao P, Zhang C, Fu Z, Chen Y, Lu A, Liu N, You Y, Pu P, Kang C, Kang C, et al: Analysis of miR-221 and p27 expression in human gliomas . Mol Med Rep 2: 651-656, 2009.
APA
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A. ... Kang, C. (2009). Analysis of miR-221 and p27 expression in human gliomas . Molecular Medicine Reports, 2, 651-656. https://doi.org/10.3892/mmr_00000152
MLA
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A., Liu, N., You, Y., Pu, P., Kang, C."Analysis of miR-221 and p27 expression in human gliomas ". Molecular Medicine Reports 2.4 (2009): 651-656.
Chicago
Lu, X., Zhao, P., Zhang, C., Fu, Z., Chen, Y., Lu, A., Liu, N., You, Y., Pu, P., Kang, C."Analysis of miR-221 and p27 expression in human gliomas ". Molecular Medicine Reports 2, no. 4 (2009): 651-656. https://doi.org/10.3892/mmr_00000152
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