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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2009 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2009 Volume 2 Issue 4

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Article

RUNX1T1 is overexpressed in imatinib mesylate-resistant cells

  • Authors:
    • Renata Binato
    • Andre Mencalha
    • Luciana Pizzatti
    • Vanessa Scholl
    • Ilana Zalcberg
    • Eliana Abdelhay

  • View Affiliations / Copyright

    Affiliations: Instituto Nacional de Câncer (INCa), Divisão de Laboratórios do CEMO, Rio de Janeiro, RJ, Brazil. rbgomes@inca.gov.br
  • Pages: 657-661
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/mmr_00000153
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Abstract

The Philadelphia (Ph) chromosome, which occurs as a result of a translocation between chromosomes 9 and 22, generates a BCR-ABL fusion oncogene in leukaemia cells. The BCR-ABL fusion protein has constitutive tyrosine kinase activity. The development of imatinib mesylate (STI571, Gleevec®), a potent and selective BCR-ABL tyrosine kinase inhibitor, represents an important advance in cancer therapy. However, inherent mechanisms confer resistance to imatinib mesylate in some leukaemia patients. In order to identify the genes potentially related to these resistance mechanisms, we examined genes differentially expressed in BCR-ABL-positive cell lines resistant to imatinib mesylate. A comparison of global gene expression using the HG-U133 2.0 plus Gene Chip array was first performed. Twenty-three genes were shown to be overexpressed in an imatinib-resistant cell line. Among these, RUNX1T1 was shown to be overexpressed in another resistant cell line and in patients resistant to imatinib mesylate. This suggests that RUNX1T1 is a putative candidate for the further study of imatinib mesylate resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Binato R, Mencalha A, Pizzatti L, Scholl V, Zalcberg I and Abdelhay E: RUNX1T1 is overexpressed in imatinib mesylate-resistant cells . Mol Med Rep 2: 657-661, 2009.
APA
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., & Abdelhay, E. (2009). RUNX1T1 is overexpressed in imatinib mesylate-resistant cells . Molecular Medicine Reports, 2, 657-661. https://doi.org/10.3892/mmr_00000153
MLA
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., Abdelhay, E."RUNX1T1 is overexpressed in imatinib mesylate-resistant cells ". Molecular Medicine Reports 2.4 (2009): 657-661.
Chicago
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., Abdelhay, E."RUNX1T1 is overexpressed in imatinib mesylate-resistant cells ". Molecular Medicine Reports 2, no. 4 (2009): 657-661. https://doi.org/10.3892/mmr_00000153
Copy and paste a formatted citation
x
Spandidos Publications style
Binato R, Mencalha A, Pizzatti L, Scholl V, Zalcberg I and Abdelhay E: RUNX1T1 is overexpressed in imatinib mesylate-resistant cells . Mol Med Rep 2: 657-661, 2009.
APA
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., & Abdelhay, E. (2009). RUNX1T1 is overexpressed in imatinib mesylate-resistant cells . Molecular Medicine Reports, 2, 657-661. https://doi.org/10.3892/mmr_00000153
MLA
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., Abdelhay, E."RUNX1T1 is overexpressed in imatinib mesylate-resistant cells ". Molecular Medicine Reports 2.4 (2009): 657-661.
Chicago
Binato, R., Mencalha, A., Pizzatti, L., Scholl, V., Zalcberg, I., Abdelhay, E."RUNX1T1 is overexpressed in imatinib mesylate-resistant cells ". Molecular Medicine Reports 2, no. 4 (2009): 657-661. https://doi.org/10.3892/mmr_00000153
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