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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2009 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2009 Volume 2 Issue 5

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Article

Electroporation of RNA stimulates immunity to an encoded reporter gene in mice

  • Authors:
    • John M. Piggott
    • Brian J. Sheahan
    • Declan M. Soden
    • Gerald C. O'Sullivan
    • Gregory J. Atkins

  • View Affiliations / Copyright

    Affiliations: Virus Group, Department of Microbiology, School of Genetics and Microbiology, The Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
  • Pages: 753-756
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/mmr_00000168
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Abstract

Electroporation is the application of high-voltage short-duration pulses to transiently permeabilize cells, permitting the cellular uptake of macromolecules, including nucleic acid. Although much attention has been focused on DNA vaccines, antigen-encoding RNA molecules may also stimulate immunity. Several methods are being examined in an effort to enhance the efficacy of nucleic acid delivery. One such method is the application of electroporation. The present study was designed to develop electroporation for use as a method of RNA delivery in conjunction with the Semliki Forest virus (SFV) RNA vector system for stimulation of immunity. Expression of SFV-based β-galactosidase and luciferase vectors was observed in the muscle after electroporation. Although some tissue damage was induced following intramuscular injection and electroporation with SFV vector RNA encoding LacZ at optimum pulse conditions, immunity to LacZ was efficiently induced. Following two immunizations, there was a higher IgG2a antibody response with the viral vector delivery and a higher IgG1 response in electroporated rSFV-LacZ RNA immunized mice.

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Copy and paste a formatted citation
Spandidos Publications style
Piggott JM, Sheahan BJ, Soden DM, O'Sullivan GC and Atkins GJ: Electroporation of RNA stimulates immunity to an encoded reporter gene in mice. Mol Med Rep 2: 753-756, 2009.
APA
Piggott, J.M., Sheahan, B.J., Soden, D.M., O'Sullivan, G.C., & Atkins, G.J. (2009). Electroporation of RNA stimulates immunity to an encoded reporter gene in mice. Molecular Medicine Reports, 2, 753-756. https://doi.org/10.3892/mmr_00000168
MLA
Piggott, J. M., Sheahan, B. J., Soden, D. M., O'Sullivan, G. C., Atkins, G. J."Electroporation of RNA stimulates immunity to an encoded reporter gene in mice". Molecular Medicine Reports 2.5 (2009): 753-756.
Chicago
Piggott, J. M., Sheahan, B. J., Soden, D. M., O'Sullivan, G. C., Atkins, G. J."Electroporation of RNA stimulates immunity to an encoded reporter gene in mice". Molecular Medicine Reports 2, no. 5 (2009): 753-756. https://doi.org/10.3892/mmr_00000168
Copy and paste a formatted citation
x
Spandidos Publications style
Piggott JM, Sheahan BJ, Soden DM, O'Sullivan GC and Atkins GJ: Electroporation of RNA stimulates immunity to an encoded reporter gene in mice. Mol Med Rep 2: 753-756, 2009.
APA
Piggott, J.M., Sheahan, B.J., Soden, D.M., O'Sullivan, G.C., & Atkins, G.J. (2009). Electroporation of RNA stimulates immunity to an encoded reporter gene in mice. Molecular Medicine Reports, 2, 753-756. https://doi.org/10.3892/mmr_00000168
MLA
Piggott, J. M., Sheahan, B. J., Soden, D. M., O'Sullivan, G. C., Atkins, G. J."Electroporation of RNA stimulates immunity to an encoded reporter gene in mice". Molecular Medicine Reports 2.5 (2009): 753-756.
Chicago
Piggott, J. M., Sheahan, B. J., Soden, D. M., O'Sullivan, G. C., Atkins, G. J."Electroporation of RNA stimulates immunity to an encoded reporter gene in mice". Molecular Medicine Reports 2, no. 5 (2009): 753-756. https://doi.org/10.3892/mmr_00000168
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