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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-October 2009 Volume 2 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

Involvement of Rho-kinase in TGF-β-stimulated heat shock protein 27 induction in osteoblasts

Hideo Natsume, Jun Mizutani, Seiji Adachi, Rie Matsushima-Nishiwaki, Chiho Minamitani, Haruhiko Tokuda, Osamu Kozawa, Takanobu Otsuka
Pages: 687-691
Published online on: 01 September 2009

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Article

Antitumor activity of an adenovirus harboring two therapeutic genes, anti-VEGF ribozyme and human IL-24, in colon cancer

Shujian Chang, Weichang Chen, Jicheng Yang, Yufeng Xie, Weihua Sheng
Pages: 693-700
Published online on: 01 September 2009

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Article

Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice

Yoko Matsuda, Hijiri Takeuchi, Masanao Yokohira, Kousuke Saoo, Kyoko Hosokawa, Keiko Yamakawa, Yu Zeng, Yukari Totsuka, Keiji Wakabayashi, Katsumi Imaida
Pages: 701-706
Published online on: 01 September 2009

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Article

Sann-Joong-Kuey-Jian-Tang increases the protein expression of microtubule-associated protein II light chain 3 in human colon cancer colo 205 cells

Chun-Yuan Cheng, Yi-Hsiang Lin, Chin-Cheng Su
Pages: 707-711
Published online on: 01 September 2009

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Article

Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma

Jing Xu, Dong Li, Zhiyuan Ke, Ruiming Liu, Gunter Maubach, Lang Zhuo
Pages: 713-718
Published online on: 01 September 2009

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Article

Shotgun proteome expression profile of microdissected superficial transitional cell carcinoma and biomarker discovery from urine

Hai-Tao Niu, Shu-Juan Li, Ting Xu, Qin-Chao Yu, Ji-Wu Chang, Guang Sun
Pages: 719-723
Published online on: 01 September 2009

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Article

Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma

Su Youn Yim, You Jin Lee, Yoen Kyung Lee, Seung Eun Jung, Ji Ha Kim, Hak Jin Kim, Beung Gu Son, Young Hoon Park, Young Guen Lee, Young Whan Choi, Dae Youn Hwang
Pages: 725-732
Published online on: 01 September 2009

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Article

Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats

Naruya Tomita, Keita Yamasaki, Mariana K. Osako, Norio Komai, Takashi Shimosato, Ryuichi Morishita
Pages: 733-738
Published online on: 01 September 2009

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Article

Enzymatic mechanism of the tumoricidal action of 4-iodo-3-nitrobenzamide

Ernest Kun, Jerome Mendeleyev, Alaeddin Hakam, Eva Kirsten
Pages: 739-742
Published online on: 01 September 2009

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Article

Inhibition of proliferation induced by anti-sense RNA of HDAC1 in MCF-7 cells

Yibao Zhu, Qinjun Wei, Yajie Lu, Jun Yao, Xin Cao
Pages: 743-747
Published online on: 01 September 2009

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Article

Hydrophilic monomers suppress the adsorption of plasma protein onto a poly(vinylidene fluoride) membrane

Akira Takahashi, Hisashi Hisatomi
Pages: 749-752
Published online on: 01 September 2009

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Article

Electroporation of RNA stimulates immunity to an encoded reporter gene in mice

John M. Piggott, Brian J. Sheahan, Declan M. Soden, Gerald C. O'Sullivan, Gregory J. Atkins
Pages: 753-756
Published online on: 01 September 2009

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Article

Egr-1 is not upregulated in response to hypoxic and oxygenation conditions in human glioblastoma in vitro

Harun M. Said, Buelent Polat, Carsten Hagemann, Giles H. Vince, Jelena Anacker, Ulrike K?mmerer, Michael Flentje, Dirk Vordermark
Pages: 757-763
Published online on: 01 September 2009

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Article

Combination of circulating CXCR4 and Bmi-1 mRNA in plasma: A potential novel tumor marker for gastric cancer

Wenrong Xu, Hongxing Zhou, Hui Qian, Xuefeng Bu, Deyu Chen, Hongbing Gu, Wei Zhu, Yongmin Yan, Fei Mao
Pages: 765-771
Published online on: 01 September 2009

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Article

Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice

Seiji Cho, Keiichi Koizumi, Nobuhiro Takeno, Shinichiro Kato, Miyuki Yamada, Isaya Hashimoto, Hiroaki Sakurai, Kazuhiro Tsukada, Ikuo Saiki
Pages: 773-777
Published online on: 01 September 2009

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Article

Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease

Mitsutoshi Oguri, Kimihiko Kato, Kiyoshi Yokoi, Tetsuro Yoshida, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Nozawa, Yoshiji Yamada
Pages: 779-785
Published online on: 01 September 2009

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Article

Quantitative analysis of vascular endothelial growth factor receptors 1 and 2 in colorectal cancer

Torben F. Hansen, Karen-Lise Garm Spindler, Karen A. Lorentzen, Dorte A. Olsen, Rikke F. Andersen, Jan Lindebjerg, Ivan Brandslund, Anders Jakobsen
Pages: 787-792
Published online on: 01 September 2009

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Article

Analysis of the R72P polymorphism of the TP53 gene in patients with invasive ductal breast carcinoma

Márcia Portela De Melo, Ana C. Bittelbrunn, Carlos H. Menke, Diego De Mendonça Uchoa, Luciana Grazziotin Rossato, Gustavo Lucena Kortmann, Sandra Leistner-Segal
Pages: 793-797
Published online on: 01 September 2009

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Article

Construction of novel conditional transgenic vectors for molecular therapy based on the Tet-On system and flanked with insulators in a single plasmid

Yan A. Wang, Zhao L. Fei, Zhi Y. Zhang, Xin Q. Jiang, Wan T. Chen, Zhu G. Wang, Jian Fei, Jian W. Zheng
Pages: 799-803
Published online on: 01 September 2009

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Article

Spectroscopic characterization of human immunodeficiency virus type-1-infected plasma by principal component analysis and soft independent modeling of class analogy of visible and near-infrared spectra

Mirza K. Bahmani, Ayyoob Khosravi, Ramin Miri, Yukie Iwabu, Kazuyoshi Ikuta, Akikazu Sakudo
Pages: 805-809
Published online on: 01 September 2009

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Article

Molecular mechanism of trifluoperazine induces apoptosis in human A549 lung adenocarcinoma cell lines

Qing Y. Chen, Li J. Wu, Yu Q. Wu, Guo H. Lu, Zhong Y. Jiang, Jian W. Zhan, Yan Jie, Jian Y. Zhou
Pages: 811-817
Published online on: 01 September 2009

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Article

Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells

Guotai Xu, Cai Zhang, Jian Zhang
Pages: 819-824
Published online on: 01 September 2009

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Article

Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors

Yong H. Han, Sung Z. Kim, Suhn H. Kim, Woo H. Park
Pages: 825-830
Published online on: 01 September 2009

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Article

Estrogen in combination with 5-azacitidine up-regulates p75NTR expression and induces apoptosis in 22Rv1 prostate cancer cells

Jian-Di Yu, Kai Yang, Qi-Qi Mao, De-Bo Kong, Xiang-Yi Zheng, Li-Ping Xie
Pages: 831-836
Published online on: 01 September 2009

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Article

Application of FDG-PET for detection of malignant lesions in patients with elevated blood tumor markers but without a history of malignancy

Hong-Wei Zhan, Wei Xu, Xiao-Juan Ye, Chun-Lei Zhao, Hong Zhang, Jing Li, Qiong Yao, Li-Jun Zhang
Pages: 837-842
Published online on: 01 September 2009

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Article

Fascin overexpression is regulated by the transactivation of the promoter but not by its hypomethylation in esophageal squamous cell carcinoma

Jian Hou, Zhang-Yan Guo, Jian-Jun Xie, En-Min Li, Li-Yan Xu
Pages: 843-849
Published online on: 01 September 2009

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Article

Microarray analysis of gene expression in the ovarian cancer cell line HO-8910 with silencing of the ZNF217 gene

Guiqin Sun, Jingxia Qin, Yuwen Qiu, Yunfei Gao, Yanhong Yu, Qinkai Deng, Mei Zhong
Pages: 851-855
Published online on: 01 September 2009

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Article

Preventative and therapeutic effects of perindopril on hepatic fibrosis induced by bile duct ligation in rats

Masaru Yeki, Masahiko Koda, Tomomitsu Matono, Takaaki Sugihara, Kazunori Maeda, Yoshikazu Murawaki
Pages: 857-864
Published online on: 01 September 2009

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Article

Topographical control of prostate cancer cell migration

Michal Sarna, Ewa Wybieralska, Katarzyna Miekus, Justyna Drukala, Zbigniew Madeja
Pages: 865-871
Published online on: 01 September 2009

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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Retraction Open Access

[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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Retraction Open Access

[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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Article Open Access

LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Review Open Access

Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Article Open Access

Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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Review Open Access

SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Retraction Open Access

[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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