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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2009 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice

  • Authors:
    • Seiji Cho
    • Keiichi Koizumi
    • Nobuhiro Takeno
    • Shinichiro Kato
    • Miyuki Yamada
    • Isaya Hashimoto
    • Hiroaki Sakurai
    • Kazuhiro Tsukada
    • Ikuo Saiki

  • View Affiliations / Copyright

    Affiliations: Department of Surgery (II), Faculty of Medicine, University of Toyama, Toyama, Japan
  • Pages: 773-777
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/mmr_00000171
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Abstract

Chemokines are known to have anti-tumor effects due to their chemoattractant properties, which stimulate the accumulation of infiltrating immune cells in tumors. CCL22 (macrophage-derived chemokine, MDC) attracts killer T?cells, helper T cells and antigen-presenting cells expressing the CCL22 receptor, CCR4. Thus, CCL22 gene expression results in the accumulation of these cells in tumors, and has been shown to suppress lung and colon cancer growth in mice. In the present study, early-stage subcutaneous tumor growth in a mouse multiple myeloma cell line stably expressing CCL22 (MPC-CCL22) was decreased compared to tumor growth in control cells (MPC-mock). However, the final extent of tumor growth in these cell lines was almost equivalent. Regulatory T cells, which express CD25, CD4 and CCR4, are known to cause immune disruption. We therefore investigated the association of regulatory T cells with the progressive decrease in CCL22 anti-tumor effect observed in late-stage experimental multiple myelomas. Tumor growth in MPC-CCL22 cells was observed to drastically decrease, to the point of complete tumor regression, when CD4 or CD25 T cells were depleted. Here, we document the drastic anti-tumor effect of a combination of CCL22 and anti-CD25 antibody on multiple myeloma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Cho S, Koizumi K, Takeno N, Kato S, Yamada M, Hashimoto I, Sakurai H, Tsukada K and Saiki I: Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. Mol Med Rep 2: 773-777, 2009.
APA
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I. ... Saiki, I. (2009). Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. Molecular Medicine Reports, 2, 773-777. https://doi.org/10.3892/mmr_00000171
MLA
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I., Sakurai, H., Tsukada, K., Saiki, I."Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice". Molecular Medicine Reports 2.5 (2009): 773-777.
Chicago
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I., Sakurai, H., Tsukada, K., Saiki, I."Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice". Molecular Medicine Reports 2, no. 5 (2009): 773-777. https://doi.org/10.3892/mmr_00000171
Copy and paste a formatted citation
x
Spandidos Publications style
Cho S, Koizumi K, Takeno N, Kato S, Yamada M, Hashimoto I, Sakurai H, Tsukada K and Saiki I: Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. Mol Med Rep 2: 773-777, 2009.
APA
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I. ... Saiki, I. (2009). Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. Molecular Medicine Reports, 2, 773-777. https://doi.org/10.3892/mmr_00000171
MLA
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I., Sakurai, H., Tsukada, K., Saiki, I."Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice". Molecular Medicine Reports 2.5 (2009): 773-777.
Chicago
Cho, S., Koizumi, K., Takeno, N., Kato, S., Yamada, M., Hashimoto, I., Sakurai, H., Tsukada, K., Saiki, I."Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice". Molecular Medicine Reports 2, no. 5 (2009): 773-777. https://doi.org/10.3892/mmr_00000171
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