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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2009 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease

  • Authors:
    • Mitsutoshi Oguri
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Tetsuro Yoshida
    • Sachiro Watanabe
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yukitoshi Aoyagi
    • Masashi Tanaka
    • Yoshinori Nozawa
    • Yoshiji Yamada

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi, Japan
  • Pages: 779-785
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/mmr_00000172
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Abstract

Although chronic kidney disease (CKD) is an important risk factor for ischemic stroke, the genetic variants that confer susceptibility to ischemic stroke in individuals with CKD remain largely unknown. We performed an association study for candidate gene polymorphisms and ischemic stroke in individuals with CKD. The study population comprised 1041 Japanese individuals with CKD, including 228 subjects with ischemic stroke and 813 controls. The genotypes of 150 polymorphisms of 127 candidate genes were determined by a method that combines polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. An initial χ2 test (false discovery rate <0.05) and subsequent multivariate logistic regression analysis with adjustment for covariates (P<0.05) revealed that the 1615G↷A (Ala539Thr) polymorphism (rs1803274) of BCHE (OR=3.33; 95% CI 1.32-8.28) and the 2445G↷A (Ala54Thr) polymorphism (rs1799883) of FABP2 (OR=1.66; 95% CI 1.01-2.70) were significantly associated with ischemic stroke. The variant alleles of BCHE and FABP2 were risk factors for ischemic stroke. A stepwise forward selection procedure demonstrated that the BCHE genotype was a significant (P<0.05) and independent determinant of ischemic stroke. Genotyping for BCHE may prove informative for the assessment of the genetic risk of ischemic stroke in Japanese individuals with CKD.

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Copy and paste a formatted citation
Spandidos Publications style
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Tanaka M, Tanaka M, et al: Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. Mol Med Rep 2: 779-785, 2009.
APA
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N. ... Yamada, Y. (2009). Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. Molecular Medicine Reports, 2, 779-785. https://doi.org/10.3892/mmr_00000172
MLA
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Tanaka, M., Nozawa, Y., Yamada, Y."Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease". Molecular Medicine Reports 2.5 (2009): 779-785.
Chicago
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Tanaka, M., Nozawa, Y., Yamada, Y."Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease". Molecular Medicine Reports 2, no. 5 (2009): 779-785. https://doi.org/10.3892/mmr_00000172
Copy and paste a formatted citation
x
Spandidos Publications style
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Tanaka M, Tanaka M, et al: Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. Mol Med Rep 2: 779-785, 2009.
APA
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N. ... Yamada, Y. (2009). Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. Molecular Medicine Reports, 2, 779-785. https://doi.org/10.3892/mmr_00000172
MLA
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Tanaka, M., Nozawa, Y., Yamada, Y."Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease". Molecular Medicine Reports 2.5 (2009): 779-785.
Chicago
Oguri, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Tanaka, M., Nozawa, Y., Yamada, Y."Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease". Molecular Medicine Reports 2, no. 5 (2009): 779-785. https://doi.org/10.3892/mmr_00000172
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