Inflammation, prostatitis, proliferative inflammatory atrophy: ‘Fertile ground’ for prostate cancer development?

Perletti,Gianpaolo; Montanari,Emanuele; Vral,Anne; Gazzano,Giacomo; Marras,Emanuela; Mione,Sylvia; Magri,Vittorio

doi:10.3892/mmr_00000211

January-February 2010 Volume 3 Issue 1

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January-February 2010 Volume 3 Issue 1

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Article

Inflammation, prostatitis, proliferative inflammatory atrophy: ‘Fertile ground’ for prostate cancer development?

Authors:
- Gianpaolo Perletti
- Emanuele Montanari
- Anne Vral
- Giacomo Gazzano
- Emanuela Marras
- Sylvia Mione
- Vittorio Magri
View Affiliations / Copyright

Affiliations: Dipartimento di Biologia Strutturale e Funzionale, Università degli Studi dell__AMB__apos;Insubria, 21052 Busto A., Italy. gianpaolo.perletti@uninsubria.it
Pages: 3-12
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Published online on: January 1, 2010

https://doi.org/10.3892/mmr_00000211
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Abstract

Inflammatory processes caused by chemical, physical or biological agents are known to be important cofactors in the pathogenesis of human cancer. In the prostate, epithelial tissue damage followed by cell regeneration in the presence of inflammation is believed to be a key event in neoplastic transformation. According to the ‘injury and regeneration’ model, inflammatory cells infiltrating the prostate release reactive species in response to bacterial/viral infection, uric acid, or dietary prostate carcinogens. Besides inducing inflammation, tissue injury by these and other agents would promote the appearance of proliferative inflammatory atrophy (PIA). A subset of proliferating atrophic cells - possibly showing stem-cell features - may be exposed to the genotoxic insult of free radicals and to an increased rate of mutations and chromosomal aberrations, ultimately leading to neoplastic initiation, promotion and progression. In the last decade, the link between inflammation and cancer and the hypothesis pointing to PIA as a risk lesion for prostate cancer have been extensively investigated at the pre-clinical, clinical, morphological, cellular and molecular levels. In this article, recent reports describing supportive or negative evidence on the link between prostate inflammation, atrophy and cancer are schematically reviewed.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inflammation, prostatitis, proliferative inflammatory atrophy: ‘Fertile ground’ for prostate cancer development?

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Abstract

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