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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2010 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2010 Volume 3 Issue 1

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Article

Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro

  • Authors:
    • Tingshu Jiang
    • Liping Zhou
    • Wenlu Zhang
    • Dan Qu
    • Xiaoman Xu
    • Ying Yang
    • Shengqi Li

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, the Shengjing Hospital of China Medical University, Liaoning 110001, P.R. China
  • Pages: 51-56
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/mmr_00000217
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Abstract

Sinomenine (SIN) is an herbal ingredient isolated from Sinomenium acutum Rehd. et Wils. We evaluated the effects of SIN on the growth and apoptosis of human lung cancer NCI-H460 cells. SIN inhibited the proliferation of the cells in a dose- and time-dependent manner. Apoptosis was confirmed by flow cytometry, the TUNEL assay and transmission electron microscopy. SIN-induced apoptosis was accompanied by the collapse of mitochondrial membrane potential, the release of cytochrome C and the activation of caspase-9 and -3. SIN also increased Bax and decreased Bcl-2 protein levels in the NCI-H460 cells. Data analysis suggested that SIN exerted a significant apoptotic effect on NCI-H460 cells through the mitochondrial pathway. SIN is therefore a promising chemopreventive candidate for lung carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang T, Zhou L, Zhang W, Qu D, Xu X, Yang Y and Li S: Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro . Mol Med Rep 3: 51-56, 2010.
APA
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., & Li, S. (2010). Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro . Molecular Medicine Reports, 3, 51-56. https://doi.org/10.3892/mmr_00000217
MLA
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., Li, S."Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro ". Molecular Medicine Reports 3.1 (2010): 51-56.
Chicago
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., Li, S."Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro ". Molecular Medicine Reports 3, no. 1 (2010): 51-56. https://doi.org/10.3892/mmr_00000217
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang T, Zhou L, Zhang W, Qu D, Xu X, Yang Y and Li S: Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro . Mol Med Rep 3: 51-56, 2010.
APA
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., & Li, S. (2010). Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro . Molecular Medicine Reports, 3, 51-56. https://doi.org/10.3892/mmr_00000217
MLA
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., Li, S."Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro ". Molecular Medicine Reports 3.1 (2010): 51-56.
Chicago
Jiang, T., Zhou, L., Zhang, W., Qu, D., Xu, X., Yang, Y., Li, S."Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro ". Molecular Medicine Reports 3, no. 1 (2010): 51-56. https://doi.org/10.3892/mmr_00000217
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