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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2010 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2010 Volume 3 Issue 1

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Article

Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro

  • Authors:
    • Guoqing Xing
    • Zhenya Zhang
    • Jiqiang Liu
    • Honghai Hu
    • Norio Sugiura

  • View Affiliations / Copyright

    Affiliations: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan. xingguoqing@hotmail.com
  • Pages: 57-61
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/mmr_00000218
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Abstract

Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), is a traditional Chinese medicine widely used for the treatment of various diseases. In the present study, we examined the antiproliferative effect and apoptosis-inducing activity of paeonol and the crude total glycosides (CTG) extracted from moutan cortex against DLD-1 human colon cancer cells in vitro. Cell viability was measured using the WST-8 assay. Apoptosis was detected by Hoechst 33258 fluorescence staining and flow cytometry. Paeonol and the CTG significantly reduced cell viability in a dose- and time-dependent manner. The induction of apoptosis in DLD-1 cells was characterized by morphological changes and an increased percentage of hypodiploid cells. After treatment for 48 h with paeonol (400 µg/ml) or CTG (200 µg/ml), the ratio of apoptotic cells reached 34.79 and 48.12%, respectively. The findings obtained indicate that paeonol and the CTG extracted from moutan cortex have a significant growth-inhibitory effect on human colon cancer cells. This effect may be related to the induction of apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Xing G, Zhang Z, Liu J, Hu H and Sugiura N: Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro . Mol Med Rep 3: 57-61, 2010.
APA
Xing, G., Zhang, Z., Liu, J., Hu, H., & Sugiura, N. (2010). Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro . Molecular Medicine Reports, 3, 57-61. https://doi.org/10.3892/mmr_00000218
MLA
Xing, G., Zhang, Z., Liu, J., Hu, H., Sugiura, N."Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro ". Molecular Medicine Reports 3.1 (2010): 57-61.
Chicago
Xing, G., Zhang, Z., Liu, J., Hu, H., Sugiura, N."Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro ". Molecular Medicine Reports 3, no. 1 (2010): 57-61. https://doi.org/10.3892/mmr_00000218
Copy and paste a formatted citation
x
Spandidos Publications style
Xing G, Zhang Z, Liu J, Hu H and Sugiura N: Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro . Mol Med Rep 3: 57-61, 2010.
APA
Xing, G., Zhang, Z., Liu, J., Hu, H., & Sugiura, N. (2010). Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro . Molecular Medicine Reports, 3, 57-61. https://doi.org/10.3892/mmr_00000218
MLA
Xing, G., Zhang, Z., Liu, J., Hu, H., Sugiura, N."Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro ". Molecular Medicine Reports 3.1 (2010): 57-61.
Chicago
Xing, G., Zhang, Z., Liu, J., Hu, H., Sugiura, N."Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro ". Molecular Medicine Reports 3, no. 1 (2010): 57-61. https://doi.org/10.3892/mmr_00000218
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