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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2010 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36

  • Authors:
    • Junping Cheng
    • Mats Engstrom
    • Tomas Ekberg
    • Marika Nestor
    • Matti Anniko
    • Vladimir Tolmachev

  • View Affiliations / Copyright

    Affiliations: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Uppsala University Hospital (Akademiska Sjukhuset), Uppsala University, Uppsala, Sweden
  • Pages: 155-160
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/mmr_00000233
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Abstract

Radionuclide imaging of head and neck squamous cell carcinoma (HNSCC) using monoclonal antibodies (MAbs) has the potential to contribute to improved diagnosis and staging, thereby making more effective treatment possible. Chimeric monoclonal antibody U36 (cMAb U36), specific to CD44v6 antigen, is a candidate for the targeting of HNSCC. The aim of this study was to compare the influence of indirect iodination via closo-dodecaborate-based linker (DABI) with the influence of direct radioiodination on the biodistribution of the chimeric anti-CD44v6 antibody U36. The study was performed using nude mice bearing UT-SCC7 HNSCC xenografts using the paired-label method. The biodistribution of cMAb U36 labelled directly with 131I and using DABI with 125I was compared in the same animals. The influence of DABI on the tumour-to-organ ratio was evaluated. For both conjugates, radioactivity uptake in blood and organs decreased with time, except in tumours and the thyroid. DABI-labelled cMAb U36 was characterised by fast blood clearance and an elevated uptake in the liver and spleen. The use of DABI enabled a 1.5 to 2-fold improvement in the tumour-to-blood and tumour-to-organ ratios in comparison with direct radioiodination, with the exception of the liver and spleen. These results indicate that DABI is a promising linker for the coupling of radioiodine to HNSCC-targeting antibodies.

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Copy and paste a formatted citation
Spandidos Publications style
Cheng J, Engstrom M, Ekberg T, Nestor M, Anniko M and Tolmachev V: The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 . Mol Med Rep 3: 155-160, 2010.
APA
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., & Tolmachev, V. (2010). The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 . Molecular Medicine Reports, 3, 155-160. https://doi.org/10.3892/mmr_00000233
MLA
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., Tolmachev, V."The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 ". Molecular Medicine Reports 3.1 (2010): 155-160.
Chicago
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., Tolmachev, V."The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 ". Molecular Medicine Reports 3, no. 1 (2010): 155-160. https://doi.org/10.3892/mmr_00000233
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng J, Engstrom M, Ekberg T, Nestor M, Anniko M and Tolmachev V: The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 . Mol Med Rep 3: 155-160, 2010.
APA
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., & Tolmachev, V. (2010). The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 . Molecular Medicine Reports, 3, 155-160. https://doi.org/10.3892/mmr_00000233
MLA
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., Tolmachev, V."The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 ". Molecular Medicine Reports 3.1 (2010): 155-160.
Chicago
Cheng, J., Engstrom, M., Ekberg, T., Nestor, M., Anniko, M., Tolmachev, V."The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36 ". Molecular Medicine Reports 3, no. 1 (2010): 155-160. https://doi.org/10.3892/mmr_00000233
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