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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2010 Volume 3 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells

  • Authors:
    • Haruhiko Tokuda
    • Seiji Adachi
    • Rie Matsushima-Nishiwaki
    • Yoshiteru Hanai
    • Shinji Takai
    • Atsushi Harada
    • Osamu Kozawa

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan. tokuda@ncgg.go.jp
  • Pages: 167-171
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/mmr_00000235
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Abstract

In our previous study, we showed that basic fibroblast growth factor (bFGF) stimulates the synthesis of vascular endothelial growth factor (VEGF) via the activation of p44/p42 mitogen-activated protein (MAP) kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the effect of minodronate, a newly developed bisphosphonate, on bFGF-induced VEGF synthesis in MC3T3-E1 cells. Minodronate significantly reduced the synthesis of VEGF induced by bFGF in a dose-dependent manner in a range between 3 and 100 µM. The bFGF-stimulated phosphorylation of p44/p42 MAP kinase and SAPK/JNK was reduced by minodronate. These results strongly suggest that minodronate suppresses bFGF-stimulated VEGF synthesis via the inhibition of p44/p42 MAP kinase and SAPK/JNK in osteoblasts.

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Copy and paste a formatted citation
Spandidos Publications style
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Hanai Y, Takai S, Harada A and Kozawa O: Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells . Mol Med Rep 3: 167-171, 2010.
APA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., & Kozawa, O. (2010). Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells . Molecular Medicine Reports, 3, 167-171. https://doi.org/10.3892/mmr_00000235
MLA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., Kozawa, O."Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells ". Molecular Medicine Reports 3.1 (2010): 167-171.
Chicago
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., Kozawa, O."Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells ". Molecular Medicine Reports 3, no. 1 (2010): 167-171. https://doi.org/10.3892/mmr_00000235
Copy and paste a formatted citation
x
Spandidos Publications style
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Hanai Y, Takai S, Harada A and Kozawa O: Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells . Mol Med Rep 3: 167-171, 2010.
APA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., & Kozawa, O. (2010). Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells . Molecular Medicine Reports, 3, 167-171. https://doi.org/10.3892/mmr_00000235
MLA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., Kozawa, O."Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells ". Molecular Medicine Reports 3.1 (2010): 167-171.
Chicago
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Hanai, Y., Takai, S., Harada, A., Kozawa, O."Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells ". Molecular Medicine Reports 3, no. 1 (2010): 167-171. https://doi.org/10.3892/mmr_00000235
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