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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2010 Volume 3 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications?

  • Authors:
    • Tomasz Grzela
    • Agata Bialoszewska

  • View Affiliations / Copyright

    Affiliations: Cell Molecular Biology Laboratory, Department of Histology and Embryology, Warsaw Medical University, PL 02-004 Warsaw, Poland. tgrzela@op.pl
  • Pages: 205-211
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/mmr_00000241
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Abstract

Venous leg ulceration is a severe complication of chronic venous insufficiency. Despite numerous studies, understanding of the possible mechanisms involved in venous ulceration development remains incomplete. It is assumed that, in addition to well-documented behavioral and/or environmental conditions, as yet poorly defined genetic risk factors may play important roles in chronic wound progression or healing. It is difficult to overestimate the clinical usefulness of genetic screening in the determination of the risk of wound development and/or its healing course. From a pharmacogenomic perspective, genetic screening may aid in the planning of individualized treatment. In addition, the detection of venous ulcer-promoting gene variants may facilitate the decision to introduce prophylaxis or, if necessary, appropriate treatment for venous insufficiency, long before a leg ulcer develops. In addition to significant economic benefits, this approach would reduce the risk of health- and life-threatening conditions. In this review, we focus on several gene mutations/polymorphisms with previously documented significance in leg ulceration pathophysiology, and briefly speculate about possible candidates for further study.

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Copy and paste a formatted citation
Spandidos Publications style
Grzela T and Bialoszewska A: Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? . Mol Med Rep 3: 205-211, 2010.
APA
Grzela, T., & Bialoszewska, A. (2010). Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? . Molecular Medicine Reports, 3, 205-211. https://doi.org/10.3892/mmr_00000241
MLA
Grzela, T., Bialoszewska, A."Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? ". Molecular Medicine Reports 3.2 (2010): 205-211.
Chicago
Grzela, T., Bialoszewska, A."Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? ". Molecular Medicine Reports 3, no. 2 (2010): 205-211. https://doi.org/10.3892/mmr_00000241
Copy and paste a formatted citation
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Spandidos Publications style
Grzela T and Bialoszewska A: Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? . Mol Med Rep 3: 205-211, 2010.
APA
Grzela, T., & Bialoszewska, A. (2010). Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? . Molecular Medicine Reports, 3, 205-211. https://doi.org/10.3892/mmr_00000241
MLA
Grzela, T., Bialoszewska, A."Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? ". Molecular Medicine Reports 3.2 (2010): 205-211.
Chicago
Grzela, T., Bialoszewska, A."Genetic risk factors of chronic venous leg ulceration: Can molecular screening aid in the prevention of chronic venous insufficiency complications? ". Molecular Medicine Reports 3, no. 2 (2010): 205-211. https://doi.org/10.3892/mmr_00000241
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