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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2010 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats

  • Authors:
    • Jin-Bo Liu
    • Lin Jia
    • Bing-Rong Li
    • Li-Zhen Lan
    • Qian Ge
    • Hong-Ting Zhen
    • Hua-Cong Deng

  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, P.R. China
  • Pages: 323-328
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/mmr_00000260
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Abstract

Adiponectin plays an important role in atherosclerosis, but its relationship with the early initiation of atherosclerosis in diabetes mellitus is still not completely understood. In this study, we defined the role of adiponectin early in the process of atherosclerosis in hyperglycemic rats. Recombinant adenovirus expressing the full-length apM1 cDNA gene (Ad-APN) was constructed and successfully transfected into hyperglycemic rats characterized by the presentation of early atherosclerosis. The levels of sICAM-1 and C-reactive protein (CRP) in serum as well as the expression of VCAM-1, ICAM-1 and MCP-1 in aortic tissue were evaluated. Serum adiponectin was significantly increased in Ad-APN-treated rats compared with Ad-βgal-treated rats. The levels of sICAM-1 and CRP in serum were dramatically reduced by 22 and 21%, respectively, in Ad-APN-treated rats. Additionally, in aortic tissue, significantly reduced mRNA levels of VCAM-1, ICAM-1 and MCP-1 were observed after Ad-APN transfection. These results suggest that, in hyperglycemic rats, adiponectin plays an inhibitory role in the early development of atherosclerosis. In conclusion, the protective effect of adiponectin is associated with the reduced activity of various inflammation-related factors.

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Jia L, Li B, Lan L, Ge Q, Zhen H and Deng H: Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats . Mol Med Rep 3: 323-328, 2010.
APA
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., & Deng, H. (2010). Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats . Molecular Medicine Reports, 3, 323-328. https://doi.org/10.3892/mmr_00000260
MLA
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., Deng, H."Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats ". Molecular Medicine Reports 3.2 (2010): 323-328.
Chicago
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., Deng, H."Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats ". Molecular Medicine Reports 3, no. 2 (2010): 323-328. https://doi.org/10.3892/mmr_00000260
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Jia L, Li B, Lan L, Ge Q, Zhen H and Deng H: Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats . Mol Med Rep 3: 323-328, 2010.
APA
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., & Deng, H. (2010). Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats . Molecular Medicine Reports, 3, 323-328. https://doi.org/10.3892/mmr_00000260
MLA
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., Deng, H."Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats ". Molecular Medicine Reports 3.2 (2010): 323-328.
Chicago
Liu, J., Jia, L., Li, B., Lan, L., Ge, Q., Zhen, H., Deng, H."Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats ". Molecular Medicine Reports 3, no. 2 (2010): 323-328. https://doi.org/10.3892/mmr_00000260
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