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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2010 Volume 3 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed

  • Authors:
    • Toshiyuki Fukao
    • Gaixiu Zhang
    • Naoki Matsuo
    • Naomi Kondo

  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan. toshi-gif@umin.net
  • Pages: 355-359
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/mmr_00000265
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Abstract

In ketone body metabolism, hepatocyte-specific silencing of the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene appears to be physiologically important to avoid a futile cycle in the liver, whereas the SCOT gene is expressed in extrahepatic tissues. It is not possible to explain hepatocyte-specific silencing by cis-elements in the 2.2-kb 5' flanking region. The molecular basis of this gene silencing is unknown thus far. In the present study, the methylation status of CpG islands around exon 1 in the SCOT gene was analyzed by sodium bisulfite treatment and by sequencing of genomic DNA from the HepG2, Chang liver and HeLa human cell lines, and also from mouse liver, heart and kidney cells. Most CpG dinucleotides in the CpG island of the human SCOT promoter region were not methylated in the DNA of HeLa and Chang cells, while HepG2 DNA was hypomethylated in this CpG island. CpG dinucleotides in the mouse SCOT CpG island were almost completely unmethylated in the liver DNA as well as in the heart and kidney DNA. CpG islands around the promoter region of the SCOT gene were hypomethylated in the DNA from both human HepG2 cells and mouse liver. Hence, methylation status does not contribute to hepatocyte-specific SCOT gene silencing.

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Copy and paste a formatted citation
Spandidos Publications style
Fukao T, Zhang G, Matsuo N and Kondo N: CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed . Mol Med Rep 3: 355-359, 2010.
APA
Fukao, T., Zhang, G., Matsuo, N., & Kondo, N. (2010). CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed . Molecular Medicine Reports, 3, 355-359. https://doi.org/10.3892/mmr_00000265
MLA
Fukao, T., Zhang, G., Matsuo, N., Kondo, N."CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed ". Molecular Medicine Reports 3.2 (2010): 355-359.
Chicago
Fukao, T., Zhang, G., Matsuo, N., Kondo, N."CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed ". Molecular Medicine Reports 3, no. 2 (2010): 355-359. https://doi.org/10.3892/mmr_00000265
Copy and paste a formatted citation
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Spandidos Publications style
Fukao T, Zhang G, Matsuo N and Kondo N: CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed . Mol Med Rep 3: 355-359, 2010.
APA
Fukao, T., Zhang, G., Matsuo, N., & Kondo, N. (2010). CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed . Molecular Medicine Reports, 3, 355-359. https://doi.org/10.3892/mmr_00000265
MLA
Fukao, T., Zhang, G., Matsuo, N., Kondo, N."CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed ". Molecular Medicine Reports 3.2 (2010): 355-359.
Chicago
Fukao, T., Zhang, G., Matsuo, N., Kondo, N."CpG islands around exon 1 in the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene are hypomethylated even in human and mouse hepatic tissues where SCOT gene expression is completely suppressed ". Molecular Medicine Reports 3, no. 2 (2010): 355-359. https://doi.org/10.3892/mmr_00000265
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