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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells

  • Authors:
    • Hui Chen
    • Song Zhang
    • Jian-Cheng Wen
    • Jia-Kun Zheng
    • Qiang Chen
    • Wen-Yu Li
    • Peng-Peng Wang
    • Lian Ma
    • Tian-Hua Huang
    • Ge Huang
    • Li-Ye Yang

  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Chaozhou Central Hospital, Chaozhou 521021, P.R. China
  • Pages: 441-448
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000277
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Abstract

The cellular origin of soft tissue sarcomas (STSs) is not fully understood. The cancer stem cell hypothesis presumes that tumors originate from the malignant transformation of stem cells. As a type of multipotent stem cell, adipose tissue-derived stromal/stem cells (ADSCs), which possess an unexpected degree of plasticity and often reside in other tissues, may represent a potential source of soft tissue sarcoma. To ascertain whether ADSCs are responsible for the formation of STSs, ADSCs from mice were cultured and treated with 3-methycholanthrene to derive transformed cells. These transformed ADSCs were then injected subcutaneously into immunodeficient mice to test their tumorigenic potential. We found that they generated several types of STSs, including synovial sarcoma, malignant fibrous histiocytoma and fibrosarcoma. This is the first study to report that ADSCs may be the potential initiating cells for synovial sarcoma. Our findings indicate that STSs might originate from malignantly transformed ADSCs.

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Copy and paste a formatted citation
Spandidos Publications style
Chen H, Zhang S, Wen J, Zheng J, Chen Q, Li W, Wang P, Ma L, Huang T, Huang G, Huang G, et al: Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells. Mol Med Rep 3: 441-448, 2010.
APA
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W. ... Yang, L. (2010). Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells. Molecular Medicine Reports, 3, 441-448. https://doi.org/10.3892/mmr_00000277
MLA
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W., Wang, P., Ma, L., Huang, T., Huang, G., Yang, L."Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells". Molecular Medicine Reports 3.3 (2010): 441-448.
Chicago
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W., Wang, P., Ma, L., Huang, T., Huang, G., Yang, L."Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells". Molecular Medicine Reports 3, no. 3 (2010): 441-448. https://doi.org/10.3892/mmr_00000277
Copy and paste a formatted citation
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Spandidos Publications style
Chen H, Zhang S, Wen J, Zheng J, Chen Q, Li W, Wang P, Ma L, Huang T, Huang G, Huang G, et al: Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells. Mol Med Rep 3: 441-448, 2010.
APA
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W. ... Yang, L. (2010). Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells. Molecular Medicine Reports, 3, 441-448. https://doi.org/10.3892/mmr_00000277
MLA
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W., Wang, P., Ma, L., Huang, T., Huang, G., Yang, L."Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells". Molecular Medicine Reports 3.3 (2010): 441-448.
Chicago
Chen, H., Zhang, S., Wen, J., Zheng, J., Chen, Q., Li, W., Wang, P., Ma, L., Huang, T., Huang, G., Yang, L."Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells". Molecular Medicine Reports 3, no. 3 (2010): 441-448. https://doi.org/10.3892/mmr_00000277
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