Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-December 2010 Volume 1 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2010 Volume 1 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung

  • Authors:
    • Akira Okimura
    • Nobuyuki Terada
    • Masaki Hata
    • Kunimitsu Kawahara
    • Teruo Iwasaki
    • Mitsunori Oota
    • Hiroshi Hirano
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka 583-8588, Japan, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Department of Surgery, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka 583-8588, Japan, Department of Pathology, Nippon Steel Hirohata Hospital, Hirohata, Hyogo 671-1122, Japan
  • Pages: 959-966
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol.2010.166
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pleomorphic carcinoma (PC) of the lung consists of an epithelial component showing the histology of poorly differentiated non-small cell carcinoma of the lung and a sarcomatous component, that is more aggressive compared to non-small cell carcinoma of the lung. To determine the differences between an epithelial component of PC and poorly differentiated non-small cell carcinoma, the expression of adhesion molecules (E-cadherin, β-catenin and N-cadherin) and transforming growth factor-β (TGF-β) was compared immunohistochemically among 14 poorly differentiated adenocarcinomas of the lung (PDAs) and 14 PCs of the lung, with an epithelial component, showing the histology of PDA. Expression levels of E-cadherin and β-catenin were significantly lower in epithelial or sarcomatous components of PCs than in PDAs while that of TGF-β was significantly higher in epithelial components of PCs than in PDAs. No significant difference was found in incidences of the expression of these molecules between epithelial and sarcomatous components of PCs. No significant difference was noted in the expression level of N-cadherin among PDAs and epithelial and sarcomatous components of PCs. The present results showed that E-cadherin and β-catenin expression is reduced and TGF-β expression is increased in epithelial components of PCs with the same histology as PDA when compared to PDAs, suggesting that an epithelial component of PC is distinct from non-small cell carcinoma with the same histology.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Corrin B, Wick MR, Chang YL, et al: Sarcomatoid carcinoma. Pathology and Genetics, Tumors of the Lung, Pleura, Thymus and Heart, World Health Organization Classification of Tumours. Travis WD, Brambilla E, Müller-Hermelink HK and Harris CC: IARC Press; Lyon: pp. 53–58. 2004

2 

Wick MR, Ritter JH and Humphrey PA: Sarcomatoid carcinomas of the lung: a clinicopathologic review. Am J Clin Pathol. 108:40–53. 1997.PubMed/NCBI

3 

Mochizuki T, Ishii G, Nagai K, et al: Pleomorphic carcinoma of the lung. Clinicopathologic characteristics of 70 cases. Am J Surg Pathol. 32:1727–1735. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Przygodzki RM, Koss MN, Moran CA, et al: Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis. Am J Clin Pathol. 106:487–492. 1996.PubMed/NCBI

5 

Bremnes RM, Veve R, Hirsch FR and Franklin WA: The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis. Lung Cancer. 36:115–124. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Charalabopoulos K, Gogali A, Kostoula OK and Constantopoulos SH: Cadherin superfamily of adhesion molecules in primary lung cancer. Exp Oncol. 26:256–260. 2004.PubMed/NCBI

7 

Jeanes A, Gottardi CJ and Yap AS: Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene. 27:6920–6929. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Makrilla N, Kollias A, Manolopoulos L and Syrigos K: Cell adhesion molecules: role and clinical significance in cancer. Cancer Invest. 27:1023–1037. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Nieman MT, Prudoff RS, Johnson KR and Wheelock MJ: N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 147:631–644. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Hazan RB, Phillips GR, Qiao RF, Norton L and Aaronson SA: Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 148:779–790. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Li G, Satyamoorthy K and Herlyn M: N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res. 61:3819–3825. 2001.PubMed/NCBI

12 

Cavallaro U: N-cadherin as an invasion promoter: a novel target for antitumor therapy? Curr Opin Investig Drugs. 5:1274–1278. 2004.PubMed/NCBI

13 

Voulgari A and Pintzas A: Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta. 1976:75–90. 2009.PubMed/NCBI

14 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Iwatsuki M, Mimori K, Yokobori T, et al: Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 101:293–299. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Rees JRE, Onwuegbusi BA, Save VE, Alderson D and Fitzgerald RC: In vivo and in vitro evidence for transforming growth factor-β1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res. 66:9583–9590. 2006.

17 

Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E and Koteish A: Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem. 282:22089–22101. 2007.

18 

Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y and Kodaira S: Transforming growth factor-β1 as a prognostic factor in pulmonary adenocarcinoma. J Clin Pathol. 47:1098–1100. 1994.

19 

Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T and Kodaira S: Expression of PDGF, IGF-II and TGF-β1 in pulmonary adnocarcinoma. Pathol Res Pract. 192:1113–1120. 1996.

20 

Robson H, Anderson E, James RD and Schofield RF: Transforming growth factor β1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients. Br J Cancer. 74:753–758. 1996.

21 

Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M and Kaibara N: The expression of transforming growth factor-β1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer. 86:1455–1462. 1999.

22 

Desruisseau S, Palmari J, Giusti C, Romain S, Martin PM and Berthois Y: Determination of TGF β1 protein level in human primary breast cancers and its relationship with survival. Br J Cancer. 94:239–246. 2006.

23 

Pelosi G, Scarpa A, Manzotti M, et al: K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung. Mod Pathol. 17:538–546. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Nakashima T, Huang C, Liu D, et al: Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients. Br J Cancer. 88:1727–1733. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zynger DL, Dimov ND, Ho LC, Laskin WB and Yeldandi AV: Differential expression of neural-cadherin in pulmonary epithelial tumours. Histopathology. 52:348–354. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Kase S, Sugio K, Yamazaki K, Okamoto T, Yano T and Sugimachi K: Expression of E-cadherin and β-catenin in human non-small cell lung cancer and the clinical significance. Clin Cancer Res. 6:4789–4796. 2000.

27 

Nozawa N, Hashimoto S, Nakashima Y, et al: Immunohistochemical α- and β-catenin and E-cadherin expression and their clinicopathological significance in human lung adenocarcinoma. Pathol Res Pract. 202:639–650. 2006.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Okimura A, Terada N, Hata M, Kawahara K, Iwasaki T, Oota M and Hirano H: Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung. Oncol Lett 1: 959-966, 2010.
APA
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., & Hirano, H. (2010). Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung. Oncology Letters, 1, 959-966. https://doi.org/10.3892/ol.2010.166
MLA
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., Hirano, H."Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung". Oncology Letters 1.6 (2010): 959-966.
Chicago
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., Hirano, H."Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung". Oncology Letters 1, no. 6 (2010): 959-966. https://doi.org/10.3892/ol.2010.166
Copy and paste a formatted citation
x
Spandidos Publications style
Okimura A, Terada N, Hata M, Kawahara K, Iwasaki T, Oota M and Hirano H: Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung. Oncol Lett 1: 959-966, 2010.
APA
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., & Hirano, H. (2010). Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung. Oncology Letters, 1, 959-966. https://doi.org/10.3892/ol.2010.166
MLA
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., Hirano, H."Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung". Oncology Letters 1.6 (2010): 959-966.
Chicago
Okimura, A., Terada, N., Hata, M., Kawahara, K., Iwasaki, T., Oota, M., Hirano, H."Expression of adhesion molecules and transforming growth factor-β in pleomorphic carcinomas of the lung". Oncology Letters 1, no. 6 (2010): 959-966. https://doi.org/10.3892/ol.2010.166
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team