Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case

  • Authors:
    • Walid Al-Achkar
    • Thomas Liehr
    • Abdulsamad Wafa
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  • Published online on: September 23, 2010     https://doi.org/10.3892/ol.2010.180
  • Pages: 951-954
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Abstract

Chronic myeloid leukemia (CML) is a pluripotent hematopoietic stem cell disorder almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11). The presence of Ph results in the formation of the BCR/ABL fusion gene, which is a constitutively activated tyrosine kinase. Approximately 1% of CML patients appear to have a Ph-negative karyotype but carry a cryptic BCR/ABL fusion that can be located by fluorescence in situ hybridization (FISH) at chromosome 22q11, 9q34 or a third chromosome. This study investigated a rare Ph-negative CML case with insertion of the 3' ABL region into the long arm of derivative chromosome 1 but lacking the 5' BCR region on der(22).
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November-December 2010
Volume 1 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al-Achkar W, Liehr T and Wafa A: Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case. Oncol Lett 1: 951-954, 2010
APA
Al-Achkar, W., Liehr, T., & Wafa, A. (2010). Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case. Oncology Letters, 1, 951-954. https://doi.org/10.3892/ol.2010.180
MLA
Al-Achkar, W., Liehr, T., Wafa, A."Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case". Oncology Letters 1.6 (2010): 951-954.
Chicago
Al-Achkar, W., Liehr, T., Wafa, A."Insertion of the 3' ABL region into the long arm of chromosome 1 in a Philadelphia chromosome-negative chronic myeloid leukemia case". Oncology Letters 1, no. 6 (2010): 951-954. https://doi.org/10.3892/ol.2010.180