Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer. Case report

  • Authors:
    • Tadahiro Shoji
    • Eriko Takatori
    • Yoshitaka Kaido
    • Seisuke Kumagai
    • Satoshi Takeuchi
    • Akira Yoshizaki
    • Toru Sugiyama
  • View Affiliations

  • Published online on: September 23, 2010     https://doi.org/10.3892/ol.2010.192
  • Pages: 1021-1024
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Abstract

We report a case of recurrent ovarian cancer in which desensitization for a carboplatin hypersensitivity reaction proved useful. The patient was a 65-year-old woman who presented with a recurrence of stage IIIc ovarian cancer. The initial chemotherapy consisted of 6 courses of paclitaxel and carboplatin. Recurrence in the pelvis, splenic hilum and para-aortic lymph nodes was detected 19 months after the final day of treatment. The patient was treated with docetaxel-carbo- platin therapy for the recurrence, but a Grade 3 hypersensitivity reaction to carboplatin was observed during the second course. Carboplatin desensitization was commenced with the third course and 6 courses were completed with no evidence of hypersensitivity reaction. The antitumor effect showed a complete response and the patient has had a disease-free survival thus far. Desensitization for patients diagnosed with a carboplatin hypersensitivity reaction appeared to be a key method of treatment for prolonging the survival time of patients with recurrent ovarian cancer.
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November-December 2010
Volume 1 Issue 6

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Spandidos Publications style
Shoji T, Takatori E, Kaido Y, Kumagai S, Takeuchi S, Yoshizaki A and Sugiyama T: Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer. Case report. Oncol Lett 1: 1021-1024, 2010
APA
Shoji, T., Takatori, E., Kaido, Y., Kumagai, S., Takeuchi, S., Yoshizaki, A., & Sugiyama, T. (2010). Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer. Case report. Oncology Letters, 1, 1021-1024. https://doi.org/10.3892/ol.2010.192
MLA
Shoji, T., Takatori, E., Kaido, Y., Kumagai, S., Takeuchi, S., Yoshizaki, A., Sugiyama, T."Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer. Case report". Oncology Letters 1.6 (2010): 1021-1024.
Chicago
Shoji, T., Takatori, E., Kaido, Y., Kumagai, S., Takeuchi, S., Yoshizaki, A., Sugiyama, T."Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer. Case report". Oncology Letters 1, no. 6 (2010): 1021-1024. https://doi.org/10.3892/ol.2010.192