Melanoma leptomeningeal dissemination following frontoparietal metastasis surgery: Case report and review of the literature

Sereno Moyano,María; Gutiérrez-Gutiérrez,Gerardo; Rodríguez‑Esteban,Isabel; Sánchez Crespo,Gemma; Casado,Enrique

doi:10.3892/ol.2010.194

November-December 2010 Volume 1 Issue 6

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November-December 2010 Volume 1 Issue 6

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Case Report

Melanoma leptomeningeal dissemination following frontoparietal metastasis surgery: Case report and review of the literature

Authors:
- María Sereno Moyano
- Gerardo Gutiérrez-Gutiérrez
- Isabel Rodríguez‑Esteban
- Gemma Sánchez Crespo
- Enrique Casado
View Affiliations / Copyright

Affiliations: Department of Medical Oncology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Neurology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Pathology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Clinical Analysis, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain
Pages: 1101-1104
|
Published online on: September 23, 2010

https://doi.org/10.3892/ol.2010.194
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Abstract

We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings suggested a subarachnoid haemorrhage (SAH) and/or meningeal carcinomatosis. The results of a cytological examination of the CSF showed neoplastic epithelial cells consistent with metastatic melanoma cells. Resection of metastatic posterior fossa lesions is often cited as a risk factor for leptomeningeal dissemination, however, when the resection is limited to the anterior fossa, this complication is relatively rare. In contrast, SAH may be a complication of leptomeningeal dissemination and responsible for acute meningeal syndrome. Treatment with high doses of corticoids did not show any improvement, and intrathecal chemotherapy was not possible due to the patient's poor functional status. She succumbed 1 week after admission.

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1	Pentheroudakis G and Pavlidis N: Management of leptomeningeal malignancy. Expert Opin Pharmacother. 6:1115–1125. 2005. View Article : Google Scholar : PubMed/NCBI
2	Bruno MK and Raizer J: Leptomeningeal metastases from solid tumours (meningeal carcinomatosis). Cancer Treat Res. 125:31–52. 2005. View Article : Google Scholar : PubMed/NCBI
3	Tarhini AA and Kirkwood JM: Clinical and immunologic basis of interferon therapy in melanoma. Ann NY Acad Sci. 1182:47–57. 2009. View Article : Google Scholar : PubMed/NCBI
4	Raizer J, Hwu W, Panageas K, et al: Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical features. Neuro Oncol. 10:199–207. 2008. View Article : Google Scholar : PubMed/NCBI
5	Sloan A, Nock C, Estein D, et al: Diagnosis and treatment of melanoma brain metastasis: a literature review. Cancer Control. 3:248–254. 2009.PubMed/NCBI
6	Chamberlain MC and Johnston SK: Neoplastic meningitis: survival as a function of cerebrospinal fluid cytology. Cancer. 115:1941–1946. 2009. View Article : Google Scholar : PubMed/NCBI
7	Vellin JF, Achim V, Sinardet D, et al: Rapidly developing leptomeningeal carcinomatosis following anterior skull base surgery: a case report. Auris Nasus Larynx. 34:565–567. 2007. View Article : Google Scholar : PubMed/NCBI
8	Yu H, Mitsumori M, Nagata Y, et al: Meningeal carcinomatosis in patients with breast cancer: report of 8 patients. Breast Cancer. 8:74–78. 2001. View Article : Google Scholar : PubMed/NCBI
9	Suki D, Abouassi H, Patel A, et al: Comparative risk of leptomeningeal disease after resection or stereotactic radiosurgery for solid tumor metastasis to the posterior fossa. J Neurosurg. 108:248–257. 2008. View Article : Google Scholar : PubMed/NCBI
10	Grossman SA and Krabak MJ: Leptomeningeal carcinomatosis. Cancer Treat Rev. 25:103–119. 1999. View Article : Google Scholar
11	Norris LK, Grossman SA and Olivi A: Neoplastic meningitis following surgical resection of isolated cerebellar metastasis: a potentially preventable complication. J Neurooncol. 32:215–233. 1997. View Article : Google Scholar
12	Van der Ree T, Dippel D, Avezaart C, Sillevis Smitt PA, Vecht CJ and van den Bent MJ: Leptomeningeal metastasis after surgical resection of brain metastases. J Neurol Neurosurg Psychiatry. 66:225–227. 1999.PubMed/NCBI
13	De Angelis LM, Mandell LR, Thaler HT, et al: The role of postoperative radiotherapy after resection of single brain metastasis. Neurosurgery. 24:798–805. 1989.PubMed/NCBI
14	Chang C, Kuwana N and Ito S: Spinal leptomeningeal metastases of giant cell glioblastoma associated with subarachnoid haemorrhage: case report. J Clin Neurosci. 8:56–59. 1998. View Article : Google Scholar : PubMed/NCBI
15	Lossos A and Siegal T: Spinal subarachnoid haemorrhage associated with leptomeningeal metastases. J Neurooncol. 12:167–171. 1992. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Melanoma leptomeningeal dissemination following frontoparietal metastasis surgery: Case report and review of the literature

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