Pituicytoma: Report of two cases

Mao,Zhigang; Xiao,Weiwei; Wang,Haijun; Li,Zhi; Huang,Quan; He,Dongsheng; Zhu,Yonghong

doi:10.3892/ol.2010.209

Pituicytoma: Report of two cases

Authors:
- Zhigang Mao
- Weiwei Xiao
- Haijun Wang
- Zhi Li
- Quan Huang
- Dongsheng He
- Yonghong Zhu
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Affiliations: Department of Neurosurgery, the First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China
Published online on: November 23, 2010 https://doi.org/10.3892/ol.2010.209
Pages: 37-41

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Abstract

This report describes two cases of pituicytoma. The two patients were female and presented with visual complaints, diabetes insipidus, headaches and menstrual disorders. The imaging characteristic was an intrasellar or suprasellar mass, and one mass originated in the pituitary stalk. The mass showed homogeneous enhancement with contrast administration. A hematoxylin and eosin stain showed a compact structure consisting of elongated, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern. Immunohistochemically, the tumor showed diffuse strong expression of S-100 protein, vimentin and epithelial membrane antigen, and glial fibrillary acidic protein was focally positive. The pituicytoma may have originated in the pituitary stalk and presented with diabetes insipidus, and the differential diagnosis should be compared with the pituitary stalk mass. Bleeding during resection was moderate, and surgery was regarded as the first choice of treatment for pituicytomas.

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