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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-February 2011 Volume 2 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review

Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review)

  • Authors:
    • Rafał Stec
    • Lubomir Bodnar
    • Marta Smoter
    • Michał Mączewski
    • Cezary Szczylik
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Military Institute of Medicine in Warsaw, 04-141 Warsaw, Poland, Department of Clinical Physiology, Medical Center of Postgraduate Education, Warsaw, Poland
  • Pages: 3-11
    |
    Published online on: November 23, 2010
       https://doi.org/10.3892/ol.2010.212
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Abstract

Colorectal cancer (CRC) is one of the most frequently occurring types of cancer. Worldwide, more than 800,000 new cases of CRC are diagnosed each year. The median ages at CRC diagnosis and death are 71 and 75 years, respectively. The majority ot patients (50-60%) with colorectal cancer are diagnosed at stage IV disease. Patients aged 65 or older are characterized by a higher incidence of significant co-morbidities, decreased regenerative capacity of bone marrow and worse general performance. Anti-neoplastic therapies used for the treatment of colorectal cancer include irinotecan, oxaliplatin, 5-fluorouracil, leucovorin, capecitabine and monoclonal antibodies. Analysis of the efficacy of the presented chemotherapeutic and chemoimmunotherapeutic regimens in the treatment of metastatic CRC in patients older than 65 and 70 years compared to ‘younger’ patients, generally demonstrated comparable efficacy, time to disease progression and overall survival. Age criterion should not be considered when assessing the eligibility of patients with metastatic CRC for treatment of the above-mentioned chemotherapeutic and chemoimmunotherapeutic regimens. Treatment should be individualized based on the potential risks and benefits anticipated for each patient.
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Copy and paste a formatted citation
Spandidos Publications style
Stec R, Bodnar L, Smoter M, Mączewski M and Szczylik C: Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review). Oncol Lett 2: 3-11, 2011.
APA
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., & Szczylik, C. (2011). Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review). Oncology Letters, 2, 3-11. https://doi.org/10.3892/ol.2010.212
MLA
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., Szczylik, C."Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review)". Oncology Letters 2.1 (2011): 3-11.
Chicago
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., Szczylik, C."Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review)". Oncology Letters 2, no. 1 (2011): 3-11. https://doi.org/10.3892/ol.2010.212
Copy and paste a formatted citation
x
Spandidos Publications style
Stec R, Bodnar L, Smoter M, Mączewski M and Szczylik C: Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review). Oncol Lett 2: 3-11, 2011.
APA
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., & Szczylik, C. (2011). Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review). Oncology Letters, 2, 3-11. https://doi.org/10.3892/ol.2010.212
MLA
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., Szczylik, C."Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review)". Oncology Letters 2.1 (2011): 3-11.
Chicago
Stec, R., Bodnar, L., Smoter, M., Mączewski, M., Szczylik, C."Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review)". Oncology Letters 2, no. 1 (2011): 3-11. https://doi.org/10.3892/ol.2010.212
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