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March-April 2011 Volume 2 Issue 2

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Article

Copy number increase of HER-2 in colorectal cancers

  • Authors:
    • Yi Xiong
    • Zhengyu Fang
    • Chao Zhang
    • Guolong Qi
    • Wenli Liu
    • Wei Zhang
    • Jun Wan
  • View Affiliations / Copyright

    Affiliations: Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen, Guangdong, P.R. China, Department of Medical Information, Medical Collage of Jinan University, Guangzhou, P.R. China, JNU-HKUST Joint Lab, Ji-Nan University, Guangdong, P.R. China
  • Pages: 331-335
    |
    Published online on: December 8, 2010
       https://doi.org/10.3892/ol.2010.225
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Abstract

HER-2 is involved in genetic instability and is overexpressed in a number of human carcinomas, including colorectal cancer (CRC). The choromosomal locus of HER-2, 17q21, is frequently amplified in breast cancer, but the correlation between copy-number variations and HER-2 overexpression in CRC has yet to be elucidated. The functional impact of such regions requires extensive investigation in large numbers of CRC samples. Case-matched tissues of colorectal adenocarcinomas and adjacent normal epithelia (n=134) were included in this study. Quantitative PCR was performed to examine the copy number and mRNA expression of HER-2 in CRC. The results showed that copy number gains of HER-2 were detected in a relatively high percentage of CRC samples (35.1%, 47 out of 134). A positive correlation was noted between the copy number increase of HER-2 and tumor progression. Furthermore, copy number gains of HER-2 showed a positive correlation with mRNA overexpression in CRC. However, the expression levels of HER-2 mRNA were also enhanced in the group of CRC samples with unaltered copy numbers. In conclusion, the findings suggest that a copy number increase of HER-2 is a potential diagnostic indicator for CRC; whether alone or in combination with other markers.
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Copy and paste a formatted citation
Spandidos Publications style
Xiong Y, Fang Z, Zhang C, Qi G, Liu W, Zhang W and Wan J: Copy number increase of HER-2 in colorectal cancers. Oncol Lett 2: 331-335, 2011.
APA
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., & Wan, J. (2011). Copy number increase of HER-2 in colorectal cancers. Oncology Letters, 2, 331-335. https://doi.org/10.3892/ol.2010.225
MLA
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., Wan, J."Copy number increase of HER-2 in colorectal cancers". Oncology Letters 2.2 (2011): 331-335.
Chicago
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., Wan, J."Copy number increase of HER-2 in colorectal cancers". Oncology Letters 2, no. 2 (2011): 331-335. https://doi.org/10.3892/ol.2010.225
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong Y, Fang Z, Zhang C, Qi G, Liu W, Zhang W and Wan J: Copy number increase of HER-2 in colorectal cancers. Oncol Lett 2: 331-335, 2011.
APA
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., & Wan, J. (2011). Copy number increase of HER-2 in colorectal cancers. Oncology Letters, 2, 331-335. https://doi.org/10.3892/ol.2010.225
MLA
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., Wan, J."Copy number increase of HER-2 in colorectal cancers". Oncology Letters 2.2 (2011): 331-335.
Chicago
Xiong, Y., Fang, Z., Zhang, C., Qi, G., Liu, W., Zhang, W., Wan, J."Copy number increase of HER-2 in colorectal cancers". Oncology Letters 2, no. 2 (2011): 331-335. https://doi.org/10.3892/ol.2010.225
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