Retrospective analysis of metastatic sarcoma patients

Nakamura,Tomoki; Matsumine,Akihiko; Matsubara,Takao; Asamuma,Kunihiro; Niimi,Rui; Uchida,Atsumasa; Sudo,Akihiro

doi:10.3892/ol.2011.238

March-April 2011 Volume 2 Issue 2

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March-April 2011 Volume 2 Issue 2

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Article

Retrospective analysis of metastatic sarcoma patients

Authors:
- Tomoki Nakamura
- Akihiko Matsumine
- Takao Matsubara
- Kunihiro Asamuma
- Rui Niimi
- Atsumasa Uchida
- Akihiro Sudo
View Affiliations / Copyright

Affiliations: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514-8507, Japan
Pages: 315-318
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Published online on: January 19, 2011

https://doi.org/10.3892/ol.2011.238
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Abstract

Numerous studies have reported the survival of metastatic sarcoma patients who have undergone either a lung metastasectomy or chemotherapy. However, little is known with regards to the clinical course of patients with bone or soft tissue sarcomas who have succumbed to disease. This study aimed to analyze the metastatic patterns of sarcoma patients and to describe the clinical course after the detection of distant metastasis. We reviewed the clinical records of 255 patients with a diagnosis of sarcoma who were referred to our institution, and found 63 patients who succumbed due to metastasis. We examined the clinical features of the initially detected distant metastases, the subsequent clinical course up to the time of patient death and the survival time of patients who died of lung metastasis. Of the 63 patients who died of distant metastasis, 52 (83%) developed lung metastasis as the first metastatic site, while 22 (35%) developed extra-pulmonary metastasis. The majority (77%; 49 of 63 patients) died of primary metastasis. While all 18 bone sarcoma patients died of lung metastasis, 11 of the 45 soft tissue sarcoma patients died of extra-pulmonary metastasis. Six patients died of brain metastasis. The survival of the patients with lung metastasis was only approximately 6 months following the cessation of treatment, regardless of the type of treatment used. These results indicate that planned follow-up and treatment of sarcomas require a precise knowledge of tumor clinical behavior, particularly of the preponderant activity.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Retrospective analysis of metastatic sarcoma patients

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Abstract

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