Gastric Ewing sarcoma/primitive neuroectodermal tumor: A case report

Inoue,Makoto; Wakai,Toshifumi; Korita,Pavel V.; Sakata,Jun; Kurosaki,Ryo; Ogose,Agira; Kawashima,Hiroyuki; Shirai,Yoshio; Ajioka,Yoichi; Hatakeyama,Katsuyoshi

doi:10.3892/ol.2011.246

March-April 2011 Volume 2 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-April 2011 Volume 2 Issue 2

Full Size Image

Case Report Open Access

Gastric Ewing sarcoma/primitive neuroectodermal tumor: A case report

Authors:
- Makoto Inoue
- Toshifumi Wakai
- Pavel V. Korita
- Jun Sakata
- Ryo Kurosaki
- Agira Ogose
- Hiroyuki Kawashima
- Yoshio Shirai
- Yoichi Ajioka
- Katsuyoshi Hatakeyama
View Affiliations / Copyright

Affiliations: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, Japan, Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, Japan, Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, Japan
Pages: 207-210
|
Published online on: January 20, 2011

https://doi.org/10.3892/ol.2011.246
Expand metrics +

Abstract

Ewing sarcoma/primitive neuroectodermal tumors (ES/PNETs) may arise in bone or soft tissue; however, these tumors rarely originate in the stomach. To the best of our knowledge, only four cases have previously been reported in the English-language literature. A 41-year-old Japanese woman was admitted with abdominal pain and underwent gastrectomy to remove the primary tumor. Immunohistochemistry, chromosomal karyotype and molecular analysis using reverse transcription-polymerase chain reaction were performed in the tumor specimens obtained. Tumor cells showed positive immunoreactivity for CD99, vimentin, CD117 (c-kit), S100, chromogranin A and synaptophysin. The tumor was a gastric ES/PNET with the EWS-FLI1 fusion gene translocation t(11;22)(q24;q12). Multiple repeat metastasectomies, as well as multi-agent chemotherapy and radiotherapy were performed for recurrent disease. Despite treatment, the patient succumbed due to progressive disease 110 months after the initial surgery for gastric ES/PNET. A review of the reported cases suggests that patients with gastric ES/PNETs have an unfavorable prognosis following resection due to the high propensity of these tumors to metastasize. Thus, multimodal treatment approaches including surgery, as well as multi-agent chemotherapy and radiotherapy may provide a survival benefit for patients with gastric ES/PNETs.

View Figures

View References

1	Kempson RL, Fletcher CDM, Evans HL, et al: Tumors of the Soft Tissues. 3rd edition. The Armed Forces Institute of Pathology; Washington, DC: pp. 444–452. 2001
2	Czekalla R, Fuchs M, Stölzle A, et al: Peripheral primitive neuroectodermal tumor of the stomach in a 14-year-old boy: a case report. Eur J Gastroenterol Hepatol. 16:1391–1400. 2004.PubMed/NCBI
3	Soulard R, Claude V, Camparo P, Dufau JP, Saint-Blancard P and Gros P: Primitive neuroectodermal tumor of the stomach. Arch Pathol Lab Med. 129:107–110. 2005.PubMed/NCBI
4	Rafailidis S, Ballas K, Psarras K, Pavlidis T, Symeonidis N, Marakis G and Sakadamis A: Primary Ewing sarcoma of the stomach – a newly described entity. Eur Surg Res. 42:17–20. 2009.
5	Colovic RB, Grubor NM, Micev MT, Matic SV, Atkinson HD and Latincic SM: Perigastric extraskeletal Ewing’s sarcoma: a case report. World J Gastroenterol. 15:245–247. 2009.PubMed/NCBI
6	Obata H, Ueda T, Kawai A, et al: Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study. Cancer. 109:767–775. 2007. View Article : Google Scholar : PubMed/NCBI
7	Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI
8	Ushigome S, Machinami R and Sorensen PH: Ewing sarcoma/ Primitive neuroectodermal tumour (PNET). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK and Mertens F: IARC Press; Lyon: pp. 298–300. 2002
9	Skubitz KM and D’Adamo DR: Sarcoma. Mayo Clin Proc. 82:1409–1432. 2007. View Article : Google Scholar
10	Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H and Salzer-Kuntschik M: MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing’s sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer. 67:1886–1893. 1991.
11	Ramani P, Rampling D and Link M: Immunocytochemical study of 12E7 in small round-cell tumours of childhood: an assessment of its sensitivity and specificity. Histopathology. 23:557–561. 1993. View Article : Google Scholar : PubMed/NCBI
12	Leavey PJ and Collier AB: Ewing sarcoma: prognostic criteria, outcomes and future treatment. Expert Rev Anticancer Ther. 8:617–624. 2008. View Article : Google Scholar : PubMed/NCBI
13	Esiashvili N, Goodman M and Marcus RB Jr: Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data. J Pediatr Hematol Oncol. 30:425–430. 2008. View Article : Google Scholar : PubMed/NCBI
14	Haeusler J, Ranft A, Boelling T, et al: The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES). Cancer. 116:443–450. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gastric Ewing sarcoma/primitive neuroectodermal tumor: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles