Association between brain natriuretic peptide and distant metastases in advanced non-small cell lung cancer patients

Masago,Katsuhiro; Fujita,Shiro; Togashi,Yosuke; Irisa,Kaoru; Sakamori,Yuichi; Hatachi,Yukimasa; Fukuhara,Akiko; Nagai,Hiroki; Kim,Young   Hak; Mio,Tadashi; Mishima,Michiaki

doi:10.3892/ol.2011.247

March-April 2011 Volume 2 Issue 2

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March-April 2011 Volume 2 Issue 2

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Article

Association between brain natriuretic peptide and distant metastases in advanced non-small cell lung cancer patients

Authors:
- Katsuhiro Masago
- Shiro Fujita
- Yosuke Togashi
- Kaoru Irisa
- Yuichi Sakamori
- Yukimasa Hatachi
- Akiko Fukuhara
- Hiroki Nagai
- Young Hak Kim
- Tadashi Mio
- Michiaki Mishima
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Affiliations: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Division of Integrated Oncology, Institute of Biomedical Research and Innovation, Kobe, Japan
Pages: 253-256
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Published online on: January 21, 2011

https://doi.org/10.3892/ol.2011.247
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Abstract

This study aimed to investigate the relationship between clinicopathological factors and plasma brain natriuretic peptide (BNP) levels in non-small cell lung cancer (NSCLC) patients. A total of 133 patients with advanced NSCLC were included in this study. The level of BNP was determined at the time of diagnosis. The BNP plasma concentration was measured using a chemiluminescent enzyme immunoassay kit. The univariate relationship between each independent clinicopathological variable and plasma BNP was examined using the Chi-square test. The survival curves were determined using the Kaplan-Meier method. According to the cut-off value of plasma BNP levels (11.5 and 22.4 pg/ml), plasma BNP negatively correlated with the presence of metastases (Chi-square test, p=0.0374 and p=0.0098, respectively). However, no significant association between patient survival time and plasma BNP levels was found. Reduced plasma BNP levels in advanced NSCLC patients with metastases were noted and the possibility was raised that BNP decreases distant metastases of advanced NSCLC patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association between brain natriuretic peptide and distant metastases in advanced non-small cell lung cancer patients

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