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Article

Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study

  • Authors:
    • Lixia Xu
    • Zhirong Zeng
    • Bin Chen
    • Xiaoqin Wu
    • Jun Yu
    • Ling Xue
    • Linwei  Tian
    • Yiming Wang
    • Minhu Chen
    • Joseph J.Y. Sung
    • Pinjin Hu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, P.R. China, Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, P.R. China, Department of Pathology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, P.R. China, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, SAR, P.R. China, Zhongshan School of Medicine and Center for Genome Research, Sun Yat-Sen University, Guangzhou, P.R. China
  • Pages: 371-377
    |
    Published online on: January 21, 2011
       https://doi.org/10.3892/ol.2011.249
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Abstract

The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clinicopathological parameters and survival. A case-control study was conducted in 1,010 gastric cancer patients and 1,500 healthy controls. Genotypes were determined by PCR-restriction fragment length polymorphism and DNA sequencing. Compared with the TT genotype, the TGFB1 -509 C allele (CT/CC) was significantly associated with a reduced risk of gastric cancer (OR, 0.71; 95% CI, 0.58-0.87; p=0.001) and certain subtypes of gastric cancer including intestinal type (OR, 0.70; 95% CI, 0.57-0.87; p=0.001), poorly differentiated (OR, 0.67; 95% CI, 0.54-0.85; p=0.001) and stage TNM III+IV (OR, 0.73; 95% CI, 0.58-0.92; p=0.008). Compared with the TGFBR2 -875 GG genotype, carriers of the A allele (AA/AG) had a significantly decreased gastric cancer risk (OR, 0.58; 95% CI, 0.62-0.91; P<0.001). A combination of the TGFB1 -509 C and TGFBR2 -875 A alleles was associated with a further decreased risk of gastric cancer (OR, 0.42; 95% CI, 0.32-0.57, p<0.001). No significant correlation was observed between polymorphisms and survival of gastric cancer patients. Our results suggest that both the TGFB1 -509 and TGFBR2 -875 polymorphisms contribute to a decreased gastric cancer risk. The TGFB1 -509 polymorphism affects certain subtypes of gastric cancer according to clinicopathological parameters. A combination of the TGFB1 -509 C and TGFBR2 -875 A alleles conferred a further decreased gastric cancer risk. These findings provide clues to the biological mechanisms that underline tumor heterogeneity.
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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Zeng Z, Chen B, Wu X, Yu J, Xue L, Tian L, Wang Y, Chen M, Sung JJ, Sung JJ, et al: Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study. Oncol Lett 2: 371-377, 2011.
APA
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L. ... Hu, P. (2011). Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study. Oncology Letters, 2, 371-377. https://doi.org/10.3892/ol.2011.249
MLA
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L., Tian, L., Wang, Y., Chen, M., Sung, J. J., Hu, P."Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study". Oncology Letters 2.2 (2011): 371-377.
Chicago
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L., Tian, L., Wang, Y., Chen, M., Sung, J. J., Hu, P."Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study". Oncology Letters 2, no. 2 (2011): 371-377. https://doi.org/10.3892/ol.2011.249
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Zeng Z, Chen B, Wu X, Yu J, Xue L, Tian L, Wang Y, Chen M, Sung JJ, Sung JJ, et al: Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study. Oncol Lett 2: 371-377, 2011.
APA
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L. ... Hu, P. (2011). Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study. Oncology Letters, 2, 371-377. https://doi.org/10.3892/ol.2011.249
MLA
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L., Tian, L., Wang, Y., Chen, M., Sung, J. J., Hu, P."Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study". Oncology Letters 2.2 (2011): 371-377.
Chicago
Xu, L., Zeng, Z., Chen, B., Wu, X., Yu, J., Xue, L., Tian, L., Wang, Y., Chen, M., Sung, J. J., Hu, P."Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study". Oncology Letters 2, no. 2 (2011): 371-377. https://doi.org/10.3892/ol.2011.249
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