Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

Ikeguchi,Masahide; Yamamoto,Manabu; Arai,Yosuke; Maeta,Yoshihiko; Ashida,Keigo; Katano,Kuniyuki; Miki,Yasunari; Kimura,Takayuki

doi:10.3892/ol.2011.254

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

Authors:
- Masahide Ikeguchi
- Manabu Yamamoto
- Yosuke Arai
- Yoshihiko Maeta
- Keigo Ashida
- Kuniyuki Katano
- Yasunari Miki
- Takayuki Kimura
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Affiliations: Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan, Marine Products Kimuraya, Co., Ltd., Sakaiminato 684-0072, Japan
Published online on: January 21, 2011 https://doi.org/10.3892/ol.2011.254
Pages: 319-322

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Abstract

Combination chemotherapy with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) or irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) has become a standard regimen for advanced or recurrent colorectal cancer. Numerous studies have reported that long-term use of FOLFOX or FOLFIRI leads to better survival for these patients. Thus, control of the toxicity of these drugs may be crucial to prolonging survival. Fucoidan is one of the major sulfated polysaccharides of brown seaweeds and exhibits a wide range of biological activities. In the present study, we analyzed the effect of fucoidan on suppressing the toxicity of anti-cancer drugs. A total of 20 patients with unresectable advanced or recurrent colorectal cancer scheduled to undergo treatment with FOLFOX or FOLFIRI were randomly allocated into a fucoidan treatment group (n=10) and a control group without fucoidan treatment (n=10). Results showed that fucoidan regulated the occurrence of fatigue during chemotherapy. Chemotherapy with fucoidan was continued for a longer period than chemotherapy without fucoidan. Additionally, the survival of patients with fucoidan treatment was longer than that of patients without fucoidan, although the difference was not significant. Thus, fucoidan may enable the continuous administration of chemotherapeutic drugs for patients with unresectable advanced or recurrent colorectal cancer, and as a result, the prognosis of such patients is prolonged.

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