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Article

Protein expression status of p53 and epidermal growth factor receptor in thymoma

  • Authors:
    • Fei Cui
    • Jianxing He
    • Jun Liu
    • Yijiang Chen
  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 0086-210029, P.R. China, Department of Thoracic Surgery, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou, P.R. China
  • Pages: 459-463
    |
    Published online on: March 14, 2011
       https://doi.org/10.3892/ol.2011.267
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Abstract

Evaluating the state of malignancy of thymoma is a challenge due to the discrepancies between pathological classifications and clinical stage criteria. Therefore, the identification of markers contributing to the assessment of the stage of malignancy of thymoma would be useful. This study aimed to evaluate the prevalence of p53 and epidermal growth factor receptor (EGFR) in thymoma, demonstrate the clinical significance and assess the potential of specific-targeted therapy. A total of 16 thymic hyperplasia patients and 43 thymoma patients were included in the study. Samples were tested for the expression of p53 and EGFR using immunohistochemistry. In the multivariate analysis, the thymoma cases were followed up to analyze the relationship between survival rates and a number of potential factors, such as p53 and EGFR. There were 21 completely resected stage Ⅱ cases which were evaluated for relapse-free time. The distribution of p53 with clinicopathological parameters was: type A/AB 57.1%, type B1 85.7%, type B2 85.7%, type B3 90.9% and type C 100%; and stage Ⅰ 90.9%, stage Ⅱ 90.9%, stage Ⅲ 100% and stage Ⅳ 100%. The EGFR-positive rates were: type A/AB 42.9%, type B1 71.4%, type B2 57.1%, type B3 90.9% and type C 100%; and stage Ⅰ 45.5%, stage Ⅱ 76%, stage Ⅲ 75% and stage Ⅳ 100%. EGFR expression correlated with tumor size, pathological classification and advanced clinical stage, whereas p53 correlated only with pathological classifications. Findings of our multivariate analysis showed that neither p53 nor EGFR are independent prognostic factors. Nevertheless, the fact that a statistical difference (p<0.05) was noted in relapse-free survival time between the EGFR-positive and EGFR-negative groups (48.182±33.757 vs. 76.3±10.339 months) suggests that EGFR plays a key role in thymoma progression. No positive results were found between the p53 groups following a survey conducted to assess relapse time. Therefore, the application of EGFR-targeting agents is warranted in invasive thymoma, whereas the targeting of p53 has yet to be elucidated.
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1 

Marx A and Muller-Hermelink H: From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments. Pathol Res Pract. 195:515–533. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Masaoka A, Monden Y, Nakahara K and Tanioka T: Follow-up study of thymomas with special reference to their clinical stages. Cancer. 48:2485–2492. 1981. View Article : Google Scholar : PubMed/NCBI

3 

Suster S: Diagnosis of thymoma. J Clin Pathol. 59:1238–1244. 2006. View Article : Google Scholar

4 

Kondo K and Monden Y: Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg. 76:878–884. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Vousden KH: Outcomes of p53 activation – spoilt for choice. J Cell Sci. 119:5015–5020. 2006.

6 

Tominaga O, Hamelin R, Remvikos Y, Salmon R and Thomas G: p53 from basic research to clinical applications. Crit Rev Oncog. 3:257–282. 1992.PubMed/NCBI

7 

Shiao YH, Palli D, Caporaso NE, et al: Genetic and immunohistochemical analyses of p53 independently predict regional metastasis of gastric cancers. Cancer Epidemiol Biomarkers Prev. 9:631–633. 2000.PubMed/NCBI

8 

Steels E, Paesmans M, Berghmans T, et al: Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis. Eur Respir J. 18:705–719. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Pectasides D, Papaxoinis G, Nikolaou M, et al: Analysis of 7 immunohistochemical markers in male germ cell tumors demonstrates the prognostic significance of p53 and MIB-1. Anticancer Res. 29:4151–4156. 2009.PubMed/NCBI

10 

Carpenter G and Cohen S: Epidermal growth factor. J Biol Chem. 265:7709–7712. 1990.

11 

Fischer O, Hart S, Gschwind A and Ullrich A: EGFR signal transactivation in cancer cells. Biochem Soc Trans. 31:1203–1208. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ionescu D, Sasatomi E, Cieply K, Nola M and Dacic S: Protein expression and gene amplification of epidermal growth factor receptor in thymomas. Cancer. 103:630–636. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Hayashi Y, Ishii N, Obayashi C, et al: Thymoma: tumour type related to expression of epidermal growth factor (EGF), EGF-receptor, p53, v-erb B and ras p21. Virchows Arch. 426:43–50. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Sasaki H, Yukiue H, Sekimura A, et al: Elevated serum epidermal growth factor receptor level in stage IV thymoma. Surg Today. 34:477–479. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Henley J, Koukoulis G and Loehrer PL Sr: Epidermal growth factor receptor expression in invasive thymoma. J Cancer Res Clin Oncol. 167–170. 2002. View Article : Google Scholar

16 

Aisner SC, Hameed MR, Wang W, et al: EGFR and C-Kit immuno-staining in advanced or recurrent thymic epithelial neoplasms staged according to the WHO: an Eastern Cooperative Oncology Group Study. American Society of Clinical Oncology. 22:96372004.

17 

Girard N, Shen R, Guo T, et al: Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas. Clin Cancer Res. 15:6790–6799. 2009. View Article : Google Scholar

18 

Suzuki E, Sasaki H, Kawano O, et al: Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. Jpn J Clin Oncol. 36:351–356. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Tomita M, Matsuzaki Y and Onitsuka T: Relationship between expression of cancer-related proteins and tumor invasiveness in thymoma. Eur J Cardiothorac Surg. 21:595–598. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Baldi A, Ambrogi V, Mineo D, et al: Analysis of cell cycle regulator proteins in encapsulated thymomas. Clin Cancer Res. 11:5078–5083. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Landolfi JA and Terio KA: Transitional cell carcinoma in fishing cats (Prionailurus viverrinus): pathology and expression of cyclooxygenase-1, -2 and p53. Vet Pathol. 43:674–681. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Detterbeck FC: Clinical value of the WHO classification system of thymoma. Ann Thorac Surg. 81:2328–2334. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Detterbeck FC and Parsons AM: Thymic tumors. Ann Thorac Surg. 77:1860–1869. 2004. View Article : Google Scholar

24 

Yin H, Du J, Lu Z, Jiao X, Wang J and Zhou X: The correlation of the World Health Organization histologic classification of thymic epithelial tumors and its prognosis: a clinicopathologic study of 108 patients from China. Int J Surg Pathol. 17:255–261. 2009. View Article : Google Scholar

25 

Riedel RF and Burfeind WR Jr: Thymoma: benign appearance, malignant potential. Oncologist. 11:887–894. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Reddy RHV, Shah R, Kumar B and Thorpe JAC: Recurrence of stage I thymoma in sternum, 13 years after ‘complete’ excision. Eur J Cardiothorac Surg. 23:134–135. 2003.PubMed/NCBI

27 

Shiao Y-H, Palli D, Caporaso NE, et al: Genetic and immunohistochemical analyses of p53 independently predict regional metastasis of gastric cancers. Cancer Epidemiol Biomarkers Prev. 9:631–633. 2000.PubMed/NCBI

28 

Bedano PM, Perkins S, Burns M, et al: A phase II trial of erlotinib plus bevacizumab in patients with recurrent thymoma or thymic carcinoma. American Society of Clinical Oncology. 26:190872008.

29 

Christodoulou C, Murray S, Dahabreh J, et al: Response of malignant thymoma to erlotinib. Ann Oncol. 19:1361–1362. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cui F, He J, Liu J and Chen Y: Protein expression status of p53 and epidermal growth factor receptor in thymoma. Oncol Lett 2: 459-463, 2011.
APA
Cui, F., He, J., Liu, J., & Chen, Y. (2011). Protein expression status of p53 and epidermal growth factor receptor in thymoma. Oncology Letters, 2, 459-463. https://doi.org/10.3892/ol.2011.267
MLA
Cui, F., He, J., Liu, J., Chen, Y."Protein expression status of p53 and epidermal growth factor receptor in thymoma". Oncology Letters 2.3 (2011): 459-463.
Chicago
Cui, F., He, J., Liu, J., Chen, Y."Protein expression status of p53 and epidermal growth factor receptor in thymoma". Oncology Letters 2, no. 3 (2011): 459-463. https://doi.org/10.3892/ol.2011.267
Copy and paste a formatted citation
x
Spandidos Publications style
Cui F, He J, Liu J and Chen Y: Protein expression status of p53 and epidermal growth factor receptor in thymoma. Oncol Lett 2: 459-463, 2011.
APA
Cui, F., He, J., Liu, J., & Chen, Y. (2011). Protein expression status of p53 and epidermal growth factor receptor in thymoma. Oncology Letters, 2, 459-463. https://doi.org/10.3892/ol.2011.267
MLA
Cui, F., He, J., Liu, J., Chen, Y."Protein expression status of p53 and epidermal growth factor receptor in thymoma". Oncology Letters 2.3 (2011): 459-463.
Chicago
Cui, F., He, J., Liu, J., Chen, Y."Protein expression status of p53 and epidermal growth factor receptor in thymoma". Oncology Letters 2, no. 3 (2011): 459-463. https://doi.org/10.3892/ol.2011.267
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