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Article

Clinicopathological and prognostic implications of genetic alterations in oral cancers

  • Authors:
    • Swapnali M. Pathare
    • Moritz Gerstung
    • Niko Beerenwinkel
    • Alejandro A. Schäffer
    • Sadhana Kannan
    • Prathamesh Pai
    • K. Alok Pathak
    • Anita M. Borges
    • Manoj B. Mahimkar
  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar Node, Navi Mumbai 410210, India, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, Computational Biology Branch, National Center for Biotechnology Information, NIH, DHHS, Bethesda, MD, USA, ECTU, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar Node, Navi Mumbai 410210, India, Tata Memorial Hospital, Tata Memorial Centre (TMC), Mumbai 400012, India, Cancer Care Manitoba, Winnipeg R3A 1R9, Canada, Department of Pathology and Laboratory Medicine, S.L. Raheja Hospital, Mumbai 400016, India
  • Pages: 445-451
    |
    Published online on: March 21, 2011
       https://doi.org/10.3892/ol.2011.271
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Abstract

This study evaluated the clinicopathological and prognostic implications of genetic alterations characterizing oral squamous cell carcinoma (OSCC). Comparative genomic hybridization was used to identify chromosomal alterations present in primary OSCCs obtained from 97 patients. In this population, tobacco use was a significant risk factor for OSCC. By contrast, the 97 samples were negative for human papillomavirus (HPV) DNA integration, which is another known risk factor for OSCC in certain populations. Results of the Fisher's exact test, followed by the Benjamini-Hochberg correction for multiple testing, showed a correlation of 7p gain and 8p loss with node-positive OSCC (p≤0.04 for both genetic alterations) and an association of 11q13 gain with high-grade OSCC (p≤0.05). Univariate Cox-proportional hazard models, also corrected for multiple testing, showed a significant association of 11q13 gain and 18q loss with decreased survival (p≤0.05). The findings were supported by multivariate analysis, which revealed that 11q13 gain and 18q loss together serve as a strong bivariate predictor of poor prognosis. In conclusion, our study has identified genetic alterations that correlate significantly with nodal status, grade and the poor survival status of OSCC. These potential biomarkers may aid the current tumor node metastasis system for better prediction of clinical outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Pathare SM, Gerstung M, Beerenwinkel N, Schäffer AA, Kannan S, Pai P, Pathak KA, Borges AM and Mahimkar MB: Clinicopathological and prognostic implications of genetic alterations in oral cancers. Oncol Lett 2: 445-451, 2011.
APA
Pathare, S.M., Gerstung, M., Beerenwinkel, N., Schäffer, A.A., Kannan, S., Pai, P. ... Mahimkar, M.B. (2011). Clinicopathological and prognostic implications of genetic alterations in oral cancers. Oncology Letters, 2, 445-451. https://doi.org/10.3892/ol.2011.271
MLA
Pathare, S. M., Gerstung, M., Beerenwinkel, N., Schäffer, A. A., Kannan, S., Pai, P., Pathak, K. A., Borges, A. M., Mahimkar, M. B."Clinicopathological and prognostic implications of genetic alterations in oral cancers". Oncology Letters 2.3 (2011): 445-451.
Chicago
Pathare, S. M., Gerstung, M., Beerenwinkel, N., Schäffer, A. A., Kannan, S., Pai, P., Pathak, K. A., Borges, A. M., Mahimkar, M. B."Clinicopathological and prognostic implications of genetic alterations in oral cancers". Oncology Letters 2, no. 3 (2011): 445-451. https://doi.org/10.3892/ol.2011.271
Copy and paste a formatted citation
x
Spandidos Publications style
Pathare SM, Gerstung M, Beerenwinkel N, Schäffer AA, Kannan S, Pai P, Pathak KA, Borges AM and Mahimkar MB: Clinicopathological and prognostic implications of genetic alterations in oral cancers. Oncol Lett 2: 445-451, 2011.
APA
Pathare, S.M., Gerstung, M., Beerenwinkel, N., Schäffer, A.A., Kannan, S., Pai, P. ... Mahimkar, M.B. (2011). Clinicopathological and prognostic implications of genetic alterations in oral cancers. Oncology Letters, 2, 445-451. https://doi.org/10.3892/ol.2011.271
MLA
Pathare, S. M., Gerstung, M., Beerenwinkel, N., Schäffer, A. A., Kannan, S., Pai, P., Pathak, K. A., Borges, A. M., Mahimkar, M. B."Clinicopathological and prognostic implications of genetic alterations in oral cancers". Oncology Letters 2.3 (2011): 445-451.
Chicago
Pathare, S. M., Gerstung, M., Beerenwinkel, N., Schäffer, A. A., Kannan, S., Pai, P., Pathak, K. A., Borges, A. M., Mahimkar, M. B."Clinicopathological and prognostic implications of genetic alterations in oral cancers". Oncology Letters 2, no. 3 (2011): 445-451. https://doi.org/10.3892/ol.2011.271
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