Increased expression of NFATc1 in giant cell lesions of the jaws, cherubism and brown tumor of hyperparathyroidism

Katsikeris N, Kakarantza-Angelopoulou E and Angelopoulos AP: Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases. Int J Oral Maxillofac Surg. 17:94–99. 1998. View Article : Google Scholar : PubMed/NCBI

De Lange J, van den Akker HP and van den Berg H: Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104:603–615. 2007.PubMed/NCBI

Von Wowern N: Cherubism: a 36-year long-term follow-up of 2 generations in different families and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90:765–772. 2000.PubMed/NCBI

Hyckel P, Berndt A, Schleier P, Clement JH, Beensen V, Peters H and Kosmehl: Cherubism - new hypotheses on pathogenesis and therapeutic consequences. J Craniomaxillofac Surg. 33:61–68. 2005. View Article : Google Scholar : PubMed/NCBI

Pecovnik Balon B and Kavalar R: Brown tumor in association with secondary hyperparathyroidism. A case report and review of the literature. Am J Nephrol. 18:460–463. 1998.PubMed/NCBI

Bell SM, Shaw M, Jou YS, Myers RM and Knowles MA: Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer. Genomics. 44:163–170. 1997. View Article : Google Scholar : PubMed/NCBI

Ueki Y, Tiziani V, Santanna C, et al: Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet. 28:125–126. 2001. View Article : Google Scholar : PubMed/NCBI

De Lange J, van Maarle MC, van den Akker HP and Redeker EJ: A new mutation in the SH3BP2 gene showing reduced penetrance in a family affected with cherubism. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103:378–381. 2007.PubMed/NCBI

Carvalho VM, Perdigao PF, Amaral FR, De Souza PE, De Marco L and Gomez RS: Novel mutations in the SH3BP2 gene associated with sporadic central giant cell lesions and cherubism. Oral Dis. 15:106–110. 2009. View Article : Google Scholar : PubMed/NCBI

Asagiri M and Takayanagi H: The molecular understanding of osteoclast differentiation. Bone. 40:251–264. 2007. View Article : Google Scholar : PubMed/NCBI

Lietman SA, Yin L and Levine MA: SH3BP2 is an activator of NFAT activity and osteoclastogenesis. Biochem Biophys Res Commun. 371:644–648. 2008. View Article : Google Scholar : PubMed/NCBI

Novack DV and Faccio R: Jawing about TNF: new hope for cherubism. Cell. 128:15–17. 2007. View Article : Google Scholar : PubMed/NCBI

Amaral FR, Brito JA, Perdigao PF, et al: NFATc1 and TNF alpha expression in giant cell lesions of the jaws. J Oral Pathol Med. 39:269–274. 2010. View Article : Google Scholar : PubMed/NCBI

Itonaga I, Hussein I, Kudo O, Sabokbar A, Watt-Smith S, Ferguson D and Athanasou NA: Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw. J Oral Pathol Med. 32:224–231. 2003. View Article : Google Scholar : PubMed/NCBI

Adachi S, Amasaki Y, Miyatake S, Arai N and Iwata M: Successive expression and activation of NFAT family members during thymocyte differentiation. J Biol Chem. 275:14708–14716. 2000. View Article : Google Scholar : PubMed/NCBI

Wisniewska M, Stanczyk M, Grzelakowska-Sztabert B and Kaminska B: Nuclear factor of activated T cells (NFAT) is a possible target for dexamethasone in thymocyte apoptosis. Cell Biol Int. 21:127–132. 1997. View Article : Google Scholar : PubMed/NCBI

Wisniewska M, Pyrzynska B and Kaminska B: Impaired AP-1 dimers and NFAT complex formation in immature thymocytes during in vivo glucocorticoid-induced apoptosis. Cell Biol Int. 28:773–780. 2004. View Article : Google Scholar : PubMed/NCBI

Abdo EN, Alves LC, Rodrigues AS, Mesquita RA and Gomez RS: Treatment of a central giant cell granuloma with intralesional corticosteroid. Br J Oral Maxillofac Surg. 43:74–76. 2005. View Article : Google Scholar : PubMed/NCBI

Carlos R and Sedano HO: Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 93:161–166. 2002. View Article : Google Scholar : PubMed/NCBI

Adornato MC and Paticoff KA: Intralesional corticosteroid injection for treatment of central giant-cell granuloma. J Am Dent Assoc. 132:186–190. 2001. View Article : Google Scholar : PubMed/NCBI

Kim HJ, Zhao H, Kitaura H, et al: Glucocorticoids and the osteoclast. Ann N Y Acad Sci. 1116:335–339. 2007. View Article : Google Scholar