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Article

Estradiol-mediated tumor neo-vascularization

  • Authors:
    • Shilpi Rajoria
    • Robert Suriano
    • Yushan L. Wilson
    • Andrea L. George
    • Jan Geliebter
    • Stimson P. Schantz
    • Raj K. K. Tiwari
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA, Department of Otolaryngology, New York Eye and Ear Infirmary, New York, NY 10003, USA
  • Pages: 453-457
    |
    Published online on: March 21, 2011
       https://doi.org/10.3892/ol.2011.283
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Abstract

Neo-vascularization is essential for tumor growth and metastasis and is presumably initiated by bone marrow-derived endothelial progenitor cells (BM-EPCs). These cells predominantly reside in the bone marrow and are recruited at sites of inflammation, tissue damage and tumors. The tissue-specific factors responsible for recruitment of BM-EPCs and neo-vascularization are the subject of intense investigation. Using bone marrow cells from Tek/green fluorescent protein (GFP) transgenic mice, we analyzed the effect of estrogen on the mobilization of BM-EPCs to orthotopically implanted cancer cells in estrogen- and non-estrogen-supplemented ovariectomized mice. The donor marrow cells were unique as they were fluorescently tagged, allowing for the tracking of their migration to the tumor tissues. Results showed that GFP + BM-EPCs were incorporated within the tumor vasculature in comparison to the sham injections. Notably, estrogen supplementation enhanced the mobilization of BM-EPCs to the tumor site. This elevation shows that estrogen may affect tumor neo-vascularization by inducing the mobilization of BM-EPCs. Understanding and characterizing the mechanism involved in the estrogen-induced mobilization of BM-EPCs may serve as a ‘Trojan horse’ in the delivery of bio-molecules that may disrupt tumor vasculogenesis and induce the targeted killing of tumor cells.
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Copy and paste a formatted citation
Spandidos Publications style
Rajoria S, Suriano R, Wilson YL, George AL, Geliebter J, Schantz SP and Tiwari RK: Estradiol-mediated tumor neo-vascularization. Oncol Lett 2: 453-457, 2011.
APA
Rajoria, S., Suriano, R., Wilson, Y.L., George, A.L., Geliebter, J., Schantz, S.P., & Tiwari, R.K. (2011). Estradiol-mediated tumor neo-vascularization. Oncology Letters, 2, 453-457. https://doi.org/10.3892/ol.2011.283
MLA
Rajoria, S., Suriano, R., Wilson, Y. L., George, A. L., Geliebter, J., Schantz, S. P., Tiwari, R. K."Estradiol-mediated tumor neo-vascularization". Oncology Letters 2.3 (2011): 453-457.
Chicago
Rajoria, S., Suriano, R., Wilson, Y. L., George, A. L., Geliebter, J., Schantz, S. P., Tiwari, R. K."Estradiol-mediated tumor neo-vascularization". Oncology Letters 2, no. 3 (2011): 453-457. https://doi.org/10.3892/ol.2011.283
Copy and paste a formatted citation
x
Spandidos Publications style
Rajoria S, Suriano R, Wilson YL, George AL, Geliebter J, Schantz SP and Tiwari RK: Estradiol-mediated tumor neo-vascularization. Oncol Lett 2: 453-457, 2011.
APA
Rajoria, S., Suriano, R., Wilson, Y.L., George, A.L., Geliebter, J., Schantz, S.P., & Tiwari, R.K. (2011). Estradiol-mediated tumor neo-vascularization. Oncology Letters, 2, 453-457. https://doi.org/10.3892/ol.2011.283
MLA
Rajoria, S., Suriano, R., Wilson, Y. L., George, A. L., Geliebter, J., Schantz, S. P., Tiwari, R. K."Estradiol-mediated tumor neo-vascularization". Oncology Letters 2.3 (2011): 453-457.
Chicago
Rajoria, S., Suriano, R., Wilson, Y. L., George, A. L., Geliebter, J., Schantz, S. P., Tiwari, R. K."Estradiol-mediated tumor neo-vascularization". Oncology Letters 2, no. 3 (2011): 453-457. https://doi.org/10.3892/ol.2011.283
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