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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients

  • Authors:
    • Qingyong Chen
    • Jun Fei
    • Lijun Wu
    • Zhongyong Jiang
    • Yuquan Wu
    • Yun Zheng
    • Guohua Lu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Disease, The 117th Hospital of PLA, Zhejiang 310013, P.R. China, Department of Respiratory Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang 310004, P.R. China
  • Pages: 693-699
    |
    Published online on: May 11, 2011
       https://doi.org/10.3892/ol.2011.302
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Abstract

The present study aimed to determine the levels of cathepsin B (cath B), cathepsin L (cath L), cystatin C, urokinase plasminogen activator (u-PA) and urokinase plasminogen activator receptor (u-PAR) in the sera of patients with lung cancer compared to healthy controls using ELISA. Concomitantly, the relationship between the components and clinicopathological prognosis was analyzed. The study included 30 healthy volunteers and 105 lung cancer patients. Blood samples were collected and cath B, cath L, cystatin C, u-PA and u-PAR measurements were made using ELISA. Results showed that the levels of cath B, cath L, cystatin C, u-PA and u-PAR were significantly higher in the patient group compared to the healthy controls. The significance was marked for cath B and mild for u-PAR in correlation with lymph node metastasis. There was no significance for other parameters. Notably, patients with a combination of high cystatin C and high cath B levels had significantly lower survival probability as compared to those with cystatin C+/cath B- or with cystatin C-/cath B-. Similarly, patients with a combination of high u-PA and u-PAR experienced significantly shorter survival. Furthermore, the univariate analysis revealed that cath B, u-PAR, lymph node metastases, stage and grade were related to survival. However, findings of the multivariate Cox analysis indicated that the sera levels of cath B, u-PAR and lymph node metastases may serve as independent prognostic variables in patients with lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Fei J, Wu L, Jiang Z, Wu Y, Zheng Y and Lu G: Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients. Oncol Lett 2: 693-699, 2011.
APA
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., & Lu, G. (2011). Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients. Oncology Letters, 2, 693-699. https://doi.org/10.3892/ol.2011.302
MLA
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., Lu, G."Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients". Oncology Letters 2.4 (2011): 693-699.
Chicago
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., Lu, G."Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients". Oncology Letters 2, no. 4 (2011): 693-699. https://doi.org/10.3892/ol.2011.302
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Fei J, Wu L, Jiang Z, Wu Y, Zheng Y and Lu G: Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients. Oncol Lett 2: 693-699, 2011.
APA
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., & Lu, G. (2011). Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients. Oncology Letters, 2, 693-699. https://doi.org/10.3892/ol.2011.302
MLA
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., Lu, G."Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients". Oncology Letters 2.4 (2011): 693-699.
Chicago
Chen, Q., Fei, J., Wu, L., Jiang, Z., Wu, Y., Zheng, Y., Lu, G."Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients". Oncology Letters 2, no. 4 (2011): 693-699. https://doi.org/10.3892/ol.2011.302
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