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July-August 2011 Volume 2 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways

  • Authors:
    • Emil Heinze
    • Grace Chan
    • Rachel Mory
    • Raz Khavari
    • Asif Alavi
    • Sue Y. Chung
    • Robert N. Nishimura
    • Richard H. Weisbart
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, USA, Department of Research, Veterans Affairs Greater Los Angeles Healthcare System (111S), North Hills, CA 91343, USA, Department of Neurology, University of California, Los Angeles, CA 90095, USA, Department of Research, Veterans Affairs Greater Los Angeles Healthcare System (111S), North Hills, CA 91343, USA
  • Pages: 665-668
    |
    Published online on: May 13, 2011
       https://doi.org/10.3892/ol.2011.307
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Abstract

Foxp3 is a nuclear transcription factor that is both a tumor suppressor factor and regulator of T-regulatory cell (Treg) function, and is a potential therapeutic target in both autoimmunity and cancer. In order to distinguish molecular pathways responsible for these separate Foxp3 functions, deletion mutants of Foxp3 proteins were transduced and analyzed for cytotoxic activity in human cancer cell lines Skov3, MDA-MB-231, MCF-7 and Jurkat. Human Foxp3 cDNA mutants were amplified and ligated to produce plasmids for direct cell transfection. Constructs were produced and confirmed by DNA sequencing. Lipofectamine 2000 was used for plasmid transfection. Foxp3 cells were then examined. The results of our experiments reveal retention of tumor suppressor function in the absence of NFAT binding and transcriptional activation required for Treg function. Our results have significant implications for the design of autoimmune and cancer therapies that target Foxp3 and Treg cells.
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Copy and paste a formatted citation
Spandidos Publications style
Heinze E, Chan G, Mory R, Khavari R, Alavi A, Chung SY, Nishimura RN and Weisbart RH: Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways. Oncol Lett 2: 665-668, 2011.
APA
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S.Y. ... Weisbart, R.H. (2011). Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways. Oncology Letters, 2, 665-668. https://doi.org/10.3892/ol.2011.307
MLA
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S. Y., Nishimura, R. N., Weisbart, R. H."Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways". Oncology Letters 2.4 (2011): 665-668.
Chicago
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S. Y., Nishimura, R. N., Weisbart, R. H."Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways". Oncology Letters 2, no. 4 (2011): 665-668. https://doi.org/10.3892/ol.2011.307
Copy and paste a formatted citation
x
Spandidos Publications style
Heinze E, Chan G, Mory R, Khavari R, Alavi A, Chung SY, Nishimura RN and Weisbart RH: Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways. Oncol Lett 2: 665-668, 2011.
APA
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S.Y. ... Weisbart, R.H. (2011). Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways. Oncology Letters, 2, 665-668. https://doi.org/10.3892/ol.2011.307
MLA
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S. Y., Nishimura, R. N., Weisbart, R. H."Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways". Oncology Letters 2.4 (2011): 665-668.
Chicago
Heinze, E., Chan, G., Mory, R., Khavari, R., Alavi, A., Chung, S. Y., Nishimura, R. N., Weisbart, R. H."Tumor suppressor and T-regulatory functions of Foxp3 are mediated through separate signaling pathways". Oncology Letters 2, no. 4 (2011): 665-668. https://doi.org/10.3892/ol.2011.307
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