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High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study

  • Authors:
    • Qiang Lin
    • Jun Wang
    • Yue'e Liu
    • Huiling Su
    • Na Wang
    • Yuehua Huang
    • Chao-Xing Liu
    • Ping Zhang
    • Yannan Zhao
    • Kun Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hebei Medical University Affiliated North China Petroleum Bureau General Hospital, Hebei 062552, P.R. China, Department of Radiation Oncology, Hebei Medical University Fourth Hospital, Shijiazhuang 050011, P.R. China, Department of Radiation Oncology, Beijing University First Hospital, Beijing10034, P.R. China
  • Pages: 669-674
    |
    Published online on: May 16, 2011
       https://doi.org/10.3892/ol.2011.317
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Abstract

The aim of this study was to evaluate the feasibility of high-dose 3-dimensional conformal radiotherapy (3DCRT) (70 Gy) with concomitant vinorelbine (NVB) plus carboplatin (CBP) chemotherapy in patients with non-small cell lung cancer (NSCLC). Patients with advanced NSCLC were treated with 3-dimensional conformal radiotherapy in conventional fractionation: 2 Gy/fraction, 1 fraction/day, 5 fractions/week; total dose 70 Gy. The radiotherapy planning of every case had met the following conditions: the percentage of total lung volume receiving 20 Gy (V20) ≤30% and the percentage of total lung volume receiving 30 Gy (V30) ≤20%. Chemotherapy was commenced on the first day of radiotherapy: NVB 25 mg/m2, day 1 and day 8, CBP at AUC of 5 mg/ml-1.min-1, day 8, repeated for 28 days, two concomitant cycles during radiotherapy, and not more than 4 cycles following radiotherapy. A total of 37 patients were recruited and each of them completed the entire radiation procedure. No Grade V toxicity was observed within the group. The hematological toxicity rates were: Grade III/IV neutropenia was observed in 18.9% (7/37) of cases, Grade III/IV thrombo-cytopenia in 8.1% (3/37) of cases, but no cases of Grade III/IV anemia were noted. For non-hematological toxicities the rates were: Grade III radiation pneumonitis, 8.1% (3/37) of cases; Grade III radiation esophagitis, 13.5% (5/37); but no cases of Grade IV/V non-hematological toxicities. High-dose 3DCRT also achieved a favorable efficacy: the complete response (CR) rate was 13.5% (5/37) and the partial response (PR) rate was 64.9% (24/37). The total response (CR+PR) rate was 78.4% (29/37). The median survival time was 12 months and the 1-year overall survival rate was 45.1%. Given that 35% of patients in the study had stage IV disease, the survival results were comparable with other similar studies. In conclusion, in our small-sample exploratory study, the high‑dose regimen of 70 Gy using 3DCRT with concomitant NVB plus CBP was feasible for patients with NSCLC. Further evaluation of this regimen is ongoing in a prospective controlled phase II trial.
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Copy and paste a formatted citation
Spandidos Publications style
Lin Q, Wang J, Liu Y, Su H, Wang N, Huang Y, Liu C, Zhang P, Zhao Y, Chen K, Chen K, et al: High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study. Oncol Lett 2: 669-674, 2011.
APA
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y. ... Chen, K. (2011). High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study. Oncology Letters, 2, 669-674. https://doi.org/10.3892/ol.2011.317
MLA
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y., Liu, C., Zhang, P., Zhao, Y., Chen, K."High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study". Oncology Letters 2.4 (2011): 669-674.
Chicago
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y., Liu, C., Zhang, P., Zhao, Y., Chen, K."High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study". Oncology Letters 2, no. 4 (2011): 669-674. https://doi.org/10.3892/ol.2011.317
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Q, Wang J, Liu Y, Su H, Wang N, Huang Y, Liu C, Zhang P, Zhao Y, Chen K, Chen K, et al: High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study. Oncol Lett 2: 669-674, 2011.
APA
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y. ... Chen, K. (2011). High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study. Oncology Letters, 2, 669-674. https://doi.org/10.3892/ol.2011.317
MLA
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y., Liu, C., Zhang, P., Zhao, Y., Chen, K."High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study". Oncology Letters 2.4 (2011): 669-674.
Chicago
Lin, Q., Wang, J., Liu, Y., Su, H., Wang, N., Huang, Y., Liu, C., Zhang, P., Zhao, Y., Chen, K."High-dose 3-dimensional conformal radiotherapy with concomitant vinorelbine plus carboplatin in patients with non-small cell lung cancer: A feasibility study". Oncology Letters 2, no. 4 (2011): 669-674. https://doi.org/10.3892/ol.2011.317
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